Searchable abstracts of presentations at key conferences in endocrinology

ea0003p195 | Neuroendocrinology | BES2002

Weight gain and obesity in patients with hypothalamic damage

Daousi C , MacFarlane I , Pinkney J

Background: Weight gain is underrecognised in patients with hypothalamic damage and the prevalence and mechanisms are poorly defined. The aim of this study was to define the diagnoses and endocrine characteristics associated with weight gain.Subjects and methods: A retrospective study of 48 patients (25 female) mean (SD) age 45.3yrs (9.8).They included 22 patients with primary hypothalamic lesions (craniopharyngiomas, Rathke's cysts and other tumours)[g...

ea0050p366 | Reproduction | SFEBES2017

Audit of endocrine investigations undertaken in females with elevated testosterone

Frank Amy R , Jeffery Jinny , Pinkney Jon , Costelloe Sean J

Background and Aims: Clinical management of women with hyperandrogenic symptoms varies widely and UK guidelines are lacking. Dependent on presentation, differential diagnoses may include thyroid dysfunction, hyperprolactinaemia, congenital adrenal hyperplasia (CAH), hypercortisolism, acromegaly and pregnancy. Women presenting with hyperandrogenic symptoms can have a normal or elevated testosterone. This study describes hormone requesting relevant to these co...

ea0050p366 | Reproduction | SFEBES2017

Audit of endocrine investigations undertaken in females with elevated testosterone

Frank Amy R , Jeffery Jinny , Pinkney Jon , Costelloe Sean J

Background and Aims: Clinical management of women with hyperandrogenic symptoms varies widely and UK guidelines are lacking. Dependent on presentation, differential diagnoses may include thyroid dysfunction, hyperprolactinaemia, congenital adrenal hyperplasia (CAH), hypercortisolism, acromegaly and pregnancy. Women presenting with hyperandrogenic symptoms can have a normal or elevated testosterone. This study describes hormone requesting relevant to these co...

ea0019p161 | Diabetes, Metabolism and Cardiovascular | SFEBES2009

MMIF but not MCP-1 is correlated with adipose-derived TNF alpha in human obesity

Kos Katarina , Wong Steve , Kerrigan David , Pinkney Jonathan , Wilding John

Background: Adipose-tissue (AT)-derived cytokines contribute to systemic inflammation and insulin resistance. The systemic inflammation observed in obesity is thought to be mainly derived from the stroma–vascular fraction of adipose tissue due to macrophage-infiltration of AT in obesity. Macrophages are thought to be recruited and trapped in AT by release of chemoattractant-molecules such as monocyte-chemoattractant-protein-1 (MCP-1) and macrophage-migration-inhibitory-fa...

ea0015p105 | Cytokines and growth factors | SFEBES2008

Unlike subcutaneous expression of IL-6 and IL-18, omental expression of IL-6, IL-18 and MCP-1 are not related to systemic cytokine levels in human obesity

Kos Katarina , Wong Steve , Kerrigan David , Wilding John , Pinkney Jonathan

Background and aims: Adipose tissue (AT) secretes cytokines which contribute to systemic inflammation in obesity. Cytokines like monocyte-chemoattractant-protein-1 (MCP-1) have also been associated with macrophage infiltration of AT in obese mice. However, it is unknown whether visceral-AT (VAT) or subcutaneous-AT (SCAT) expression is related to serum levels of these cytokines in humans.Methods: Morbidly-obese non-diabetic subjects undergoing bariatric s...

ea0015p173 | Endocrine tumours and neoplasia | SFEBES2008

The management of multiple endocrine neoplasia type 1: 5-year experience of a multidisciplinary clinic

White Helen , Blair Jo , Weber Astrid , Pinkney Jonathan , MacFarlane Ian

The multiple endocrine neoplasia (MEN) clinic at our hospital was established in 2002 with the aim of providing integrated, comprehensive and expert regional care to patients with MEN syndrome. The clinical team consists of an adult endocrinologist, a paediatric endocrinologist, a clinical geneticist and an endocrine surgeon.In 2002, 16 patients with MEN type 1 from five different kindred were seen. These patients had previously been attending a combinat...

ea0011p622 | Neuroendocrinology and behaviour | ECE2006

The influence of growth hormone replacement (GHR) in adults with GH deficiency (GHD) on body composition, basal metabolic rate, physical activity and ingestive behaviour

Deepak D , Daousi C , Wilding JP , Pinkney J , Macfarlane IA

Objectives: GHR in adults with GHD favourably effects body composition (reduces fat and increases lean body mass) although body weight usually remains unchanged. However the effect of GHR on ingestive behaviour and voluntary physical activity in adults has not been studied.Methods: We studied 10 hypopituitary adults (8 males, 2 females, mean age 49.7 years) with severe GHD (mean peak GH response to glucagon 3.26 mU/l, baseline IGF-1 level 14.5 nmol/L) be...

ea0007p86 | Endocrine tumours and neoplasia | BES2004

A clinic for multiple endocrine neoplasia highlights needs for greater family awareness of type 1 MEN and for genetic testing of other family members

Pinkney J , MacFarlane I , Ellard S , Cave-Bigley D

Background: The availability of genetic testing has major implications for family management in MEN syndromes. In order to offer systematic genetic and endocrine screening for type 1 and type 2 MEN we invited patients with possible MEN syndromes to a dedicated clinic.Outcomes: In the first year 16 subjects (from 12 families) were seen, with a total of 28 previous or current tumours (12 hyperparathyroidism, 10 pituitary and 6 foregut tumours). Eight subje...

ea0015p341 | Thyroid | SFEBES2008

Specialist endocrine care for all hyperthyroid patients?

Evans Kate , Coupe Aileen , Mascas Ramona , Pilianidis George , Foote John , Browne Duncan , Pinkney Jon

Objectives: To establish the proportion of patients locally with potentially significant thyroid pathology not receiving specialist endocrine input. To look at the management of hyperthyroid patients within the Endocrinology service.Patients and methods: Utilising the laboratory database, 121 patients identified (97 female, 24 male; age range 17–93 years, average 55 years) with TFTs suggesting hyperthyroidism (raised fT4/fT3, and/or suppressed TSH) ...

ea0007p24 | Cytokines and growth factors | BES2004

Excessive daytime sleepiness associated with hypercytokinaemia in POEMS

Wong S , Cresswell P , English P , Wilding J , Huda M , Pazmany L , Pinkney J , Hart I

The multisystem disorder POEMS (polyneuropathy, organomegaly, endocrinopathy, monoclonal gammopathy, and skin changes) is a rare plasma cell dyscrasia. Elevated cytokines may contribute to its pathogenesis. We describe a POEMS patient with elevated plasma cytokines and excessive daytime sleepiness (EDS).A 39-year-old white woman with IgA lambda and IgG kappa paraproteinaemia, peripheral axonal sensorimotor neuropathy, moderate anascara, skin thickening a...