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ea0011p793 | Thyroid | ECE2006

Reverse Transcriptase (RT) inhibitors down regulate tumor growth, induce cell differentiation and re-establish iodine uptake in human thyroid anaplastic carcinoma in vitro and in vivo

Landriscina M , Fabiano A , Altamura S , Bagalà C , Piscazzi A , Maiorano N , Giorgino F , Barone C , Cignarelli M

RT-coding genes are expressed at very low levels in differentiated, non pathological tissues, while are significantly up-regulated in undifferentiated and transformed cells, suggesting a direct correlation between the level of expression of RT and the proliferative state of the cell. Either nevirapine and efavirenz, two RT inhibitors, used in the therapy of AIDS, reversibly down-regulate cell proliferation and induce differentiation in several human tumor cell lines.<p cla...

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Endocrine Abstracts

Reverse Transcriptase (RT) inhibitors down regulate tumor growth, induce cell differentiation and re-establish iodine uptake in human thyroid anaplastic carcinoma in vitro and in vivo

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