Searchable abstracts of presentations at key conferences in endocrinology

ea0021p97 | Clinical practice/governance and case reports | SFEBES2009

The relationship between electrolyte disturbance and treatment with proton pump inhibitors

Pokrajac Ana , Stephens William

Up-to-date, there have been 7 case reports of hypomagnesaemia associated with hypocalcaemia and hypokalaemia in patients on long-term treatment with proton-pump inhibitors (PPIs). The suggestion is that these reports present a tip of an iceberg in clinical practice. Inspired by a case of severe symptomatic electrolyte loss, which was corrected by discontinuation of PPIs, we performed an audit of a potential relationship between hypomagnesaemia and PPIs in our hospital.<p c...

ea0007p168 | Neuroendocrinology and behaviour | BES2004

Variability in GH assays undermines the value of consensus criteria for the diagnosis of adult GH deficiency and acromegaly

Pokrajac-Simeunovic A , Wieringa G , Ellis A , Trainer P

There is increasing reliance on published consensus criteria for clinical decision-making in states of GH excess and deficiency. NICE eligibility criteria for GH treatment include a peak GH response <9 mU/L during an ITT. To determine the adequacy of GH assay performance for diagnosing GH deficiency (GHD), we have assessed the variability in 101 UKNEQAS reported results from a single sample with a value close to 9.0 mU/L. For all laboratories (n=101) median GH was 11.1 mU/L...

ea0050ep005 | Adrenal and Steroids | SFEBES2017

A rare occurence of adrenal leiomyosarcoma

Sharma Aditi , Lewington-Gower Elisa , Palazzo Fausto , Pokrajac Ana

Leiomyosarcoma is a rare, malignant tumour that can arise from smooth muscle cells anywhere in the body; common sites include uterus, GI tract and retroperitoneum. We report an unusual case of a patient with an adrenal incidentaloma confirmed as a leiomyosarcoma on histology.A 61-year-old Caucasian female was investigated for chronic abdominal pain. CT scan of the abdomen and pelvis did not show any pathology other than an inci...

ea0050ep044 | Clinical Biochemistry | SFEBES2017

Investigating an isolated serum alkaline phosphatase: an incidental mediastinal seminoma

Avari Parizad , Shapriya Kavita , Rustin Gordon , Pokrajac Ana

Serum alkaline phophatase (ALP) may be released from various sources, including liver, bone, thyroid, intestine and placenta. Herein, we describe a rare case of an isolated serum ALP rise initially dismissed, and later resulting in an incidental finding of a mediastinal seminoma.A 56-year-old gentleman was referred to the Endocrinology Outpatients by his general practitioner, with a 1-month history of presumed post-viral fatig...

ea0050ep005 | Adrenal and Steroids | SFEBES2017

A rare occurence of adrenal leiomyosarcoma

Sharma Aditi , Lewington-Gower Elisa , Palazzo Fausto , Pokrajac Ana

Leiomyosarcoma is a rare, malignant tumour that can arise from smooth muscle cells anywhere in the body; common sites include uterus, GI tract and retroperitoneum. We report an unusual case of a patient with an adrenal incidentaloma confirmed as a leiomyosarcoma on histology.A 61-year-old Caucasian female was investigated for chronic abdominal pain. CT scan of the abdomen and pelvis did not show any pathology other than an inci...

ea0050ep044 | Clinical Biochemistry | SFEBES2017

Investigating an isolated serum alkaline phosphatase: an incidental mediastinal seminoma

Avari Parizad , Shapriya Kavita , Rustin Gordon , Pokrajac Ana

Serum alkaline phophatase (ALP) may be released from various sources, including liver, bone, thyroid, intestine and placenta. Herein, we describe a rare case of an isolated serum ALP rise initially dismissed, and later resulting in an incidental finding of a mediastinal seminoma.A 56-year-old gentleman was referred to the Endocrinology Outpatients by his general practitioner, with a 1-month history of presumed post-viral fatig...

ea0034p414 | Thyroid | SFEBES2014

Audit of thyroid surgery outcomes for benign thyroid disease at west Hertfordshire hospitals NHS trust 2010–2012

Wijetilleka Sajini , Mills Edouard , Pokrajac Ana , Ostberg Julia

Background: Surgery has a significant role in the management of benign thyroid disease, necessitating pre-operative evaluation and appreciation of possible complications. These include hypoparathyroidism and hypothyroidism. We compared outcomes of our benign thyroid disease patients requiring surgery to national standards set by the British Thyroid Association.Method: Outcomes for patients operated between December 2010 and December 2012 with benign dise...

ea0031p105 | Clinical practice/governance and case reports | SFEBES2013

A peculiar case of a dog bite

Arul Devah Vilashini , Pokrajac Ana , Savage Mark , Malik Isha

A 59-year-old gentleman presented to the Medical Admission Unit with facial and ankle oedema following a dog bite. He did not have any significant past medical history. Initially, he was treated for angioedema. His oedema worsened to anasarca, blood pressure rose and was found to be hypokalaemic. Echocardiogram showed a normal left ventricular ejection fraction. Urine protein creatinine ratio was <0.5 g/24 h. Vasculitic and autoimmune screen were negative. Eight weeks late...

ea0008p23 | Cytokines and growth factors | SFE2004

Variability in IGF-I assay performance undermines its contribution to the management of GH axis disorders

Pokrajac-Simeunovic A , Wark G , Wieringa GE , Trainer PJ

IGF-I is a marker of activity of the growth axis. It is accepted that the interpretation of IGF-I values requires age- and gender-specific reference ranges (RR).We have studied IGF-I assay performance by circulating 2 blood samples with different clinical scenarios to 23 centers [IDS-OCTEIA (n=2), DPC-Immulite (3), DPC-Immulite 2000 (4), in-house RIA (1), Nichols-Advantage (10) and Nichols-IRMA (3)] participating in the UK-NEQAS IGF-I scheme. Participant...

ea0065p76 | Adrenal and Cardiovascular | SFEBES2019

Factitious Addison’s disease in a young adolescent with type 1 diabetes

Bahowairath Fatima , Mateen Abdul Jamil , Jones Bryony , Ogilvie Arla , Pokrajac Ana

Hypoglycaemia is a common side effect of insulin treatment in patients with type 1 diabetes mellitus (T1DM). A 16-year old girl with T1DM presented with a recurrent hypoglycaemia, despite insulin dose reduction. Differential diagnosis included: overdose of insulin, Addison’s disease, hyperthyroidism, insulinoma and anti-insulin antibodies. She was admitted to the hospital for observation and investigations. She had a low random cortisol level, leading us to start steroids...