Endocrine Abstracts

Postmenopausal osteoporosis is a chronic condition requiring long-term treatment. Based on personalized patient care the physician should decide the optimal treatment strategy, namely the use of the available osteoanabolic and antiresorptive agents, sequentially or even in combination, in the most effective and safe way. Transitioning from one antiresorptive to another is probably the most common treatment sequence in clinical practice. In this context transition to a potent o...

Introduction: Low bone density is a frequent finding in both women and men of older age. There is not enough data about bone density in younger adults and especially men. In this study we measured bone density in healthy males per decade of age.Method: We measured bone density (BMD), T-score, Z-score and body mass index (BMI) in 1902 healthy men, age 20–59 years old. The study population was divided into four groups according to th...

Introduction: The recent ADA and EASD algorithm for the treatment of type 2 DM suggests addition of basal insulin or GLP-1 agonist to pre-existing treatment when glycemic control is not achieved.Aim: Compare efficacy and safety of exenatide (E) versus insulin Glargine (G) added after metformin monotherapy.Patients and methodOur study was open labeled, non- randomized, retrospective and included 48 patients, 1...

Teriparatide (TPTD – recombinant human parathyroid hormone 1–34) markedly increases bone mineral density (BMD) and reduces fracture risk. Sequential treatment with an antiresorptive agent is believed to preserve or further increase BMD. Strontium ranelate (SR) is thought to uncouple bone remodeling resulting in increased BMD and reduced fracture risk. In this prospective study, we aimed to evaluate the effect of SR on BMD in women with established osteoporosis previo...

Objective: To assess the regulation of parathormone (PTH) and serum calcium (s-Ca) in patients, on follow-up over a long time period of four years, who have primary hyperparathyroidism (pHPT) and whose condition is non-operable or who are not willing to undergo surgery.Methods: Initially, 17 patients with documented pHPT were recruited and treated with calcimimetic cinacalcet at a dose calculated according to s-Ca levels (≤11 mg/dl or >11 mg/dl...

Objective: Human immunodeficiency virus (HIV)-infected patients demonstrate an increased risk of osteoporosis and fractures. The pathophysiology of HIV-induced bone loss is complex and remains largely unknown. Recent studies have identified a molecular signature of small non-coding RNAs (microRNAS) in patients with osteoporosis, but data are lacking in HIV-infected patients. The aim of the present study was to investigate the expression profile of microRNAs related to bone met...

Objectives: To evaluate the skeletal profile of paediatric patients with cancer at diagnosis.Methods: Children diagnosed with cancer in our Oncology Centre were recruited during a two-year period and underwent metabolic bone profile and dual-energy X-ray absorptiometry (DXA) at the time of diagnosis.Results: 88 children were evaluated (51 boys, 53 prepubertal), aged 7.6 ± 4.6 years. Of those, 50 were diagnosed with haematologi...

Background: Epigenetic changes appear to be implicated in the development of parathyroid tumors. In this study we investigated the microRNA expression profile in the serum and tissue samples from patients with primary hyperparathyroidism (PHP) due to sporadic parathyroid adenomas (SPAs).Methods: Our study cohort consisted of 40 patients with PHP due to SPAs that underwent parathyroidectomy (PTX).MicroRNA extraction was performed fr...

Introduction: Hajdu Cheney Syndrome (HCS) is a rare genetic autosomal dominant disorder affecting multiple organ systems, characterized by distinctive facial features, acroosteolysis and severe osteoporosis. In a limited number of cases, the disease appears in association with polycystic kidney disease (PKD) or Crohn’s disease (CD). Splenomegaly has also been reported. Heterozygous gain-of-function mutations in NOTCH2 gene have been confirmed to be the cause of H...

Introduction: Acromegaly is characterized by high cardiovascular morbidity and mortality. Oxidative stress and endothelial dysfunction are underlying mechanisms of atherosclerosis. The aim of this study was to evaluate the blood redox status and endothelial function by means of nitric oxide (NO) levels in patients with acromegaly.Description of methods/design: Total antioxidant capacity (TAC), catalase activity and glutathione concentration (GSH), as mea...