Searchable abstracts of presentations at key conferences in endocrinology

ea0021ye1.1 | Alternative careers for basic and clinical scientists | SFEBES2009

The ‘darkside’ – pharmaceutical industry for endocrinologists

Porter John

For most trainees there is a well-worn path to a consultant post in the NHS. There are however alternatives to this career path- either temporarily or long term. I am one of a number of endocrinologists working in the pharmaceutical industry as medical advisers, clinical research physicians, and medical directors. I will describe my pathway from training in paediatric endocrinology to the industry. I will consider some of the challenges and differences from working in the NHS....

ea0056oc4.5 | Novel insights into prediabetes and type 2 diabetes | ECE2018

The impact of prediabetes in lung function: data from the ILERVAS project

Sanchez Enric , Betriu Angels , de la Torre Manuel Sanchez , Purroy Francesc , Fernandez Elvira , Lopez-Cano Carolina , Portero-Otin Manuel , Farras Cristina , Elias Marta , Lecube Albert

Background and aims: There are growing evidence supporting the deleterious effect of type 2 diabetes (T2D) on respiratory function and sleep breathing disorders. However, there is no information about the characteristics of lung function in the prediabetes stage.Methods: We assessed pulmonary function in 3,455 non-diabetic subjects, aged between 45 and 70 years, without vascular disease nor chronic pulmonary obstructive disease from the cross-sectional s...

ea0060p02 | (1) | UKINETS2018

Overview of neuroendocrine patient demographics and outcomes in the Leicestershire region

de Groot Emily , Chauhan Meera , Porter Sarah , Iwuji Chinenye

Neuroendocrine tumours (NETs) are rare cancers originating from neuroendocrine cells. The estimated prevalence is 35 per 100,000 people per year. A comparative review was conducted at the University Hospitals of Leicester (UHL) to determine the outcomes of treated neuroendocrine patients.Methods: Patients were identified via pharmacy records of Lanreotide, from April 2009 – March 2018. Clinical data was obtained from hospital notes and histopatholog...

ea0004p89 | Steroids | SFE2002

USE OF MUTAGENESIS TO STUDY THE TRANSLOCATION OF ANNEXIN 1 ACROSS THE CELL MEMBRANE

Solito E , Liu Q , Porter L , Buckingham J

Annexin 1 (ANXA1) belongs to a well-conserved superfamily of structurally-related Ca2+ and phospholipid-binding proteins. We first described its induction and role as a mediator of glucocorticoid (GC) actions within the host defence and neuroendocrine systems. In addition we provided evidence that an extracellular pool of ANXA1 is responsible for many of the regulatory actions of the protein, particularly in the pituitary gland where ANXA1 exported from folliculoste...

ea0081ep70 | Adrenal and Cardiovascular Endocrinology | ECE2022

Adverse events associated with supraphysiological glucocorticoid dosing in congenital adrenal hyperplasia (CAH): results of a structured literature review

Sharma Vijay , Coope Helen , Maskin Kamran , Parviainen Lotta , Porter John , Withe Michael , Barnes Anne-Marie

Objectives: Congenital adrenal hyperplasia (CAH) is a rare condition caused by enzyme deficiency in cortisol biosynthesis. Patients with CAH require lifelong therapy, with the aim of replacing deficient hormones (cortisol +/− aldosterone) and reducing excess androgen production. Guidelines state that the lowest effective glucocorticoid (GC dose) should be used; however, current GC therapy is suboptimal, and supraphysiological GC doses are used to reduce excess androgens....

ea0081ep94 | Adrenal and Cardiovascular Endocrinology | ECE2022

The burden of illness associated with adolescent and adult congenital adrenal hyperplasia: results of a structured literature review

Sabar Uzmah , Coope Helen , Maskin Kamran , Parviainen Lotta , Porter John , Withe Mike , Woods Matthew

Objectives: Congenital adrenal hyperplasia (CAH) is a rare condition caused by enzyme deficiency in cortisol biosynthesis. The aim of this study was to evaluate the burden of illness associated with child/adolescent and adult CAH.Methods: A structured, comprehensive literature review was conducted to identify articles describing the burden and treatment landscape of CAH. Literature databases (MEDLINE, Embase, the Cochrane Library and EconLit), websites a...

ea0065p270 | Neuroendocrinology | SFEBES2019

Antisense oligonucleotides as a novel medical therapy for Cushing’s disease

Whatmore Jacob , Alzahrani Ahmed , Porter Julie , Kemp Helen , Newell-Price John

Introduction: Cushing’s disease (CD) is a rare but devastating condition, caused by hypersecretion of adrenocorticotropic hormone (ACTH) from a corticotroph adenoma in the anterior pituitary. CD is associated with a five-fold excess mortality and clinical features including hypertension, diabetes mellitus, osteoporosis, and depression. First-line treatment is transsphenoidal surgery, but this is effective in only 65% of cases and the relapse rate is high. Other treatment ...

ea0049gp172 | Obesity | ECE2017

Lipolytic effects of endogenous 3-iodothyronamine (T1AM) and synthetic analog SG-2 in vivo and in cultured adipocytes

Sabatini Martina , Rogowski Michael P , Alpergin Ebru S Selen , Assadi-Porter Fariba , Zucchi Riccardo , Chiellini Grazia

3-Iodothyronamine (T1AM) is a hormone like molecule structurally similar to TH, that has been reported to modulate energy metabolism by favoring lipid over glucose catabolism. To better understand the role played by T1AM on the regulation of lipid metabolism, in the present study we administered spontaneously obese mice with T1AM at two different dosages (10 and 25 mg/kg per day) for 7 days and the effects on body weight (BW) and lipid profiles were examined. In addition a flu...

ea0059p125 | Neuroendocrinology and pituitary | SFEBES2018

Anti-POMC siRNA reduces ACTH secretion in an in vitro model of Cushing’s disease

Alzahrani Ahmed , Foulkes Elizabeth , Porter Julie , Kemp Elizabeth , Newell-Price John

Context: Cushing’s disease (CD) results from the release of high levels of adrenocorticotrophic hormone (ACTH) from a pituitary adenoma. Increased ACTH secretion stimulates excess cortisol production, causing weight gain, hypertension, diabetes and depression. The only curative treatment is transsphenoidal surgery, but the rate of recurrence is high and there is a lack of suitable medical therapies. RNA-interference is a mechanism of post-transcriptional gene silencing th...

ea0070oc1.7 | Adrenal and Cardiovascular Endocrinology | ECE2020

Comparative proteomic analysis of different bilateral adrenocortical hyperplasia

Berthon Annabel , Cologna Stephanie , Blank Paul , Hannah-Shmouni Fady , Bertherat Jerome , Porter Forbes , Stratakis Constantine

Bilateral Adrenal Hyperplasias (BAH) are responsible for approximately 10% of ACTH-independent Cushing syndrome and are classified as either micronodular or macronodular. Whereas Primary Pigmented Nodular Adrenocortical Disease (PPNAD) and isolated Micronodular Adrenal Disease (iMAD) are two types of micronodular hyperplasia, Primary Macronodular Adrenal Hyperplasia (PMAH) is a macronodular BAH. These tumors are classified differently based on clinical, histological and geneti...