Endocrine Abstracts

Background: Raised blood pressure (BP) in adolescents with type 1 Diabetes Mellitus (T1DM) has been associated with adverse cardiovascular outcomes independently of raised HbA1c. It is therefore of critical importance that these patients are identified early and appropriate treatment instigated. Of concerns, studies have recognised suboptimal management of hypertension in most of these young people, allowing them to succumb to complications of diabetes with hypertension in the...

Ovariectomy of immature female rats, results in significant decreased parameters in different organs. Previously we found that estradiol-17b (E2) restored these parameters in the different organs of ovariectomized female rats (Ovx) to values obtained in intact immature female rats. E2 also stimulated creatine kinase specific activity (CK) a hormonal-responsive marker in organs containing estrogen receptors. In the present study, we compared the effects of...

Vitamin D metabolites modulate creatine kinase specific activity (CK) in cultured skeletal cells. In this study we assess the effect of vitamin D metabolites on CK in rat epiphyseal cartilage (Ep) and diaphyseal bone (Di). Female or male Wistar- derived rats were used either as intact or after gonadectomy (Ovx or cast respectively), and treatments started 2 weeks post surgery. Rats were injected daily for 1, 2 or 8 weeks with the less-calcemic vitamin D analogs CB 1093 (CB), J...

We examined the response of rat female pituitary at different metabolic stages to treatments with estrogenic compounds and vitamin D analogs. Immature or ovariectomized (Ovx) female rats, responded by increased creatine kinase specific activity (CK) to estradiol-17β (E2), genistein (G), daidzein (D), biochainin A (BA), quecertin (Qu), carboxy- G (cG), carboxy- BA (cBA) and raloxifene (Ral). The response was inhibited when Ral was injected together with the estr...

Vitamin D receptors are widely expressed in the skeletal system, and vitamin D and its metabolites and analogs, exert a variety of biological activities such as regulation of cellular proliferation and differentiation, cell calcium transients and energy metabolism in vitro. The latter is exerted through the control of the brain type isozyme of creatine kinase specific activity (CK), which serves to provide a readily available reservoir for ATP generation under increased worklo...

Background: The use of CSII in children with T1DM is increasing. Several meta-analyses have concluded that there is an improvement in glycaemic control with CSII but most of these investigations have included adults and have been of short duration (<6 months). Our aim was to assess the medium term impact of CSII on HbA1c levels in patients managed with CSII in one region of The UK.Methods: Data was collected retrospectively from 7 centres within Nort...