Endocrine Abstracts

Introduction: Hypocalcemia has been linked to a decreased myocardial performance and even congestive heart failure, while acute chest-pain as leading symptom of hypocalcemia is an unusual presentation.Case report: A 29-year-old Caucasian man presented to the emergency department with relapsing chest-pain since several days, lasting seconds sometimes lasting several minutes, radiating to the left shoulder and combined with mild tingling in the neck. A det...

Objective: To find a relation between thyroid parameters (thyroxin serum level, thyroid antibodies, thyroid gland volume and ultrasound texture) and serum level of selenium.Background: Selenium deficiency can lead to a decrease of triiode-thyronine in peripheral tissues. Changes in thyroid hormone production can be reflected in followed thyroid parameters.Methods: In 33 patients ultrasound examination of thyroid gland was performed...

Introduction: Anti-C1q antibodies have been implicated in the pathogenesis of systemic lupus erythematosus. We have previously shown that anti-C1q antibodies are also linked to autoimmune thyroid disorders (AITD). The aim of this study was to assess the occurrence of anti-C1q antibodies in pregnant women with AITD.Methods: Serum anti-C1q antibodies were measured during the 9–11th gestational weeks in 103 pregnant women screened positive for AITD, an...

Introduction: Central hypothyroidism is rare, estimated to occur in 1:20,000 to 1:80,000 in the general population. Pituitary mass lesions and adverse effects of their treatment are the most common causes of central hypothyroidism. In recent years, the incidence of pituitary hormonal deficiencies as adverse effects of novel molecular targeting anticancer drugs has risen sharply. Especially checkpoint inhibitors are associated with partial or complete hypopituitarism. In this r...

Introduction: Latent toxoplasmosis, a zoonosis caused by protozoan Toxoplasma gondii, is the most widespread human parasitosis in developed countries (prevalence 20–80%). Upon infection, T. gondii stays in human organism lifelong. It has been linked to several autoimmune diseases, including autoimmune thyroid disease (AITD). The aim of our study was to assess the impact of latent T. gondii infection on the prevalence of AITD in pregnancy with re...

Background: Early miscarriages are of multifactorial origin. Subclinical thyroid dysfunction belongs to the common causes. Thyroid dysfunction in pregnancy is caused mainly by thyroid autoimmunity and/or iodine deficiency. The Czech Republic belongs to countries with sufficient iodine intake. The aim of the study was to determine iodine status in women after early miscarriages (n=183) and to compare it with randomly chosen age-comparable euthyroid women without previo...

Introduction: The guidelines of American Thyroid Association from 2011 include age over 30 as one of the risk factors for hypothyroidism in pregnancy. The aim of our study was to verify whether age increases the risk of autoimmune thyroid diseases (AITD) in pregnant women.Methods: We performed a cross-sectional study in 5223 unselected consecutive pregnant women in the 9th–12th gestational weeks. In a single laboratory, we measured serum concentrati...

Introduction: The utility of screening for antibodies against thyroperoxidase (TPOAb) in early pregnancy remains controversial. The aim of our retrospective follow-up study was to examine the thyroid function of initially euthyroid TPOAb+ women at a longer period after delivery.Methods: We invited 822 women screened positive for thyroid disorders in the first trimester of pregnancy (9th–12th gestational week) for follow-up. This included measurement...

Background: Etiology of infertility and miscarriages is multifactorial. Negative impact of overt thyroid dysfunction on fertility, pregnancy and development of offspring is known. Moreover, even presence of euthyroid autoimmune thyroid diseases may increase risk of miscarriages. The prevalence of positive antibodies to thyroid peroxidase (TPOAb) ranges 9–39% in women with recurrent miscarriages and 0–37% in controls. The aim of the study was to compare serum concentr...

Background: Autoantibodies directed against complement C1q (anti-C1q) have been described in a number of systemic autoimmune disorders. In systemic lupus erythematosus, they are strongly associated with proliferative lupus nephritis. However, no study has focused on the presence of anti-C1q in organ specific autoimmune disorders. The aim of this study was to determine the prevalence of anti-C1q in autoimmune thyroid disorders (AITD).Methods: Serum levels...