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ea0011p516 | Endocrine tumours and neoplasia | ECE2006

mRNA expression of somatostatin receptor subtypes in pheochromocytomas/paragangliomas

Mannelli M , Gelmini S , Malentacchi F , Simi L , Gaglianò MS , Ercolino T , Becherini L , Valeri A , Pratesi C , Orlando C

Somatostatin (sst) receptors are expressed in many tissues and multiple subtypes are often present in the same cells. Their activation by endogenous sst as well as by sst-analogues leads to inhibition of secretion and growth in some tumor, such as the neuroedocrine ones.Pheochromocytomas (Pheos) and paragangliomas (PGLs) are neural crest-derived tumors which can be sympathetic or parasympathetic in origin and present themselves as sporadic or familial. T...

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ea0026p361 | Adrenal medulla | ECE2011

Head and neck paragangliomas: genetic spectrum and clinical variability in 101 consecutive patients

Piccini Valentina , Rapizzi Elena , Bacca Alessandra , Di Trapani Giuseppe , Pulli Raffaele , Giache Valentino , Zampetti Benedetta , Canu Letizia , Faggiano Antongiulio , Deiana Luca , Mariotti Stefano , Ambrosio Maria Rosaria , Zatelli Maria Chiara , Parenti Gabriele , Colao Annamaria , Pratesi Carlo , Bernini Gianpaolo , Ercolino Tonino , Mannelli Massimo

Purpose: To genotype patients with headneck paragangliomas (HNPGL) and evaluate the percentage and types of germ-line mutations in patients classified according to family history (FH) and clinical presentation.Design: In total, 101 consecutive patients with HNPGL were examined for mutations in SDHB, SDHC, SDHD. SDHAF2 and VHL genes by PCR/sequencing.According to a careful FH, clinical, laboratory (including meta...

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Endocrine Abstracts

mRNA expression of somatostatin receptor subtypes in pheochromocytomas/paragangliomas

Head and neck paragangliomas: genetic spectrum and clinical variability in 101 consecutive patients

BiosciAbstracts