Endocrine Abstracts

To better understand the molecular and cellular nature of paediatric combined pituitary hormone deficiency diseases, our laboratory has recently generated a novel mouse model of the severe paediatric diseases caused by mutations in the LHX3 transcription factor gene. Through gene targeting, we have produced an Lhx3 W227Ter mouse modeling the LHX3 W224Ter (loss of carboxyl terminus) human disease. Patients with the W224Ter mutation are of short stature and ...

Our goal is to better understand the molecular and cellular nature of paediatric combined pituitary hormone deficiency diseases in order to facilitate improved diagnosis, treatment, and family counselling. LIM-homeodomain transcription factors regulate many aspects of development and mutations in the genes that encode these regulatory proteins are associated with several diseases. The LHX3 LIM-homeodomain protein is critical for pituitary gland organogenesis and some nervous s...

Childhood obesity is a serious public health challenge. Bariatric surgery is gaining popularity as a treatment modality for severely obese adolescents.Backgrounds: To report the safety and 1 year outcome data on morbidly obese adolescents that underwent bariatric surgery at a tertiary hospital in the UK.Methods: A retrospective review of patients (mean preoperative BMI 50.4 kg/m2; mean BMI SDS +4.2) who underwent bariatr...

Introduction: One of the main difficulties in the study of gastroenteropancreatic neuroendocrine tumors (GEP-NETs) is their wide heterogeneity and variable outcome. Several potential influencing factors on patient survival have been recently identified. These factors could help predict patients’ prognosis.Objectives: Analysis of long-term survival of our GEP-NETs cohort according to the presence of metastatic disease, tumor grade, age, sex, tumor fu...

Context: T regulatory type 1 (Tr1) cells are a subpopulation of T lymphocytes (CD4+CD49+LAG-3+IL-10+) lymphocytes that exerts a significant immunosuppressive effect. However, its possible role in autoimmune thyroid disease (AITD) had not been explored so far.Objective: To analyze the levels and function of Tr1 cells in peripheral blood and thyroid tissue of patients with AITD.Design: Cases and controls, observational study.<p c...

Peter J Fuller, Prince Henry’s Institute, Clayton, Victoria, Australia. AbstractProfessor Fuller is an NHMRC Senior Principal Research Fellow at Prince Henry's Institute of Medical Research in Melbourne where is the Associate Director and Head of the Steroid Receptor Biology Group. He is also Director of the Endocrinology Unit at the Monash Medical Centre/Southern Health and an Adjunct Professor in Medicine and ...

Introduction: Nutritional status in patients with neuroendocrine tumors (NETs), especially with gastroenteropancreatic origin, may be affected and have an impact on prognosis and survival. Different techniques are currently available to assess nutritional status, but not all of them are accessible in routine clinical practice. In this context, Body composition of NET patients was calculated by computed tomography (CT) at L3 level to evaluate its importance on clinical prognosi...

Introduction: Type 2 Diabetes Mellitus (T2DM) is a multifactorial and complex chronic disease characterized by insulin resistance and a dysfunctional adipose tissue. T2DM patients usually present a state of low-grade inflammation due to a dysregulation of the cytokine production. Consequently, this seems to contribute to insulin resistance and beta cell failure associated with the progression of this disease.Objective: To examine expression of Interleuki...

Introduction: Lenvatinib is an oral tyrosine kinase inhibitor (TKI) used for treatment of progressive, clinically significant or symptomatic disease in patients with iodine-refractory differentiated thyroid cancer (DTC).Objective: To describe our clinical experience with lenvatinib in patients with iodine-refractory differentiated thyroid cancer.Methods: Restrospective cohort study of patients with iodine-refractory differentiated ...

Robert McLachlanProfessor Robert McLachlan, FRACP, PhD is a Principal Research Fellow of the Australian NH&MRC and Director of Clinical Research at Prince Henry’s Institute of Medical Research in Melbourne, Australia. His interests include male reproductive endocrinology and the evaluation and management of male infertility, and androgen physiology. He is Deputy Director of Endocrinolog...