Endocrine Abstracts

Objectives: The value of ultrasound in functional disorders can be significant. That is why the question arises on the use of ultrasound examination of thyroid gland and its echogenity as a screening method in early detection of disfunctions, primarily subclinical and clinical forms of hypothyreosis.Methods: Testing included 328 patients. All examinees underwent ultrasound examination of thyroid gland, the blood was taken for determination of FT4</s...

Introduction: Adrenal incidentalomas are defined as adrenal lesions incidentally discovered during radiological imaging of the abdomen without prior suspicion of adrenal disease. Approximately 70% of adrenal incidentalomas are non-functional adenomas. Pheochromocytoma presents only 5–7% of the remaining functional incidentalomas. Asymptomatic pheochromocytoma-incidentaloma is usually smaller than 1 cm. Large pheochromocytoma, incidentally found, without any clinical signs...

Introduction: The aim of this study was to compare prolactin receptor gene (Prlr) expression in the duodenum, vertebra and kidney, during physiological and medicamentous hyperprolactinaemia.Methods: Wistar female rats 18 weeks old were divided into: Group P: nine rats, 3 week pregnant; Group M: ten rats that were intramuscular administrated Sulpirid (10 mg/kg) twice daily for 3 weeks; and age matched nulliparous rats as a control group: ten rats...

Relationship of body weight and blood pressure is very complex and still incompletely explained. Obesity, especially visceral, is one of the strongest predictors of arterial hypertension. Hypertension is six times higher in obese than in lean people, with its prevalence increases with an increase in BMI progressively. The mechanisms underlying hypertension in obese are not fully defined. The aim of this research was to determine the influence of various parameters on blood pre...

C reactive protein is a sensitive marker of subclinical inflammation. C-reactive protein is associated with obesity, diabetes mellitus and increased cardiovascular risk. The mechanism of elevated CRP levels could have connections with insulin resistance. Inflammation seems to have significant role in pathogenesis of diabetes and cardiovascular disease. The aim of this study is to show that the subjects with greater insulin resistance, measured by HOMA-IR have higher levels of ...

Fat tissue is highly active tissue, both metabolically and as endocrine tissue, which produced large number of bioactive peptides, known as adipocitokines. They seem to contribute in pathogenesis of obesity, insulin resistance, diabetes mellitus type 2, hypertension, hyperlipidemia, and vascular disease. Adipocitokines and low grade inflammation could be connection between obesity and coexisting diseases. This is the reason we believe that body weight reduction could have posi...

Background: This study was conducted to determine whether prolactin (PRL) influences radiological findings of benign breast lesions.Patients and methods: We observed 50 patients with nipple discharge: 23 patients with normal serum prolactin levels (group 1; n=23) and 27 patients with hyperprolactinemia (group 2a; n=27). Patients observed during this study underwent breast ultrasonography (US) and mammography. Patients with hyperprolactinemi...

Objectives: It has been reported that metformin administration lowered TSH levels in patients with type 2 diabetes mellitus and hypothyreosis. The aim of the study was to investigate effect of metformin on TSH levels in type 2 diabetic patients with primary hypothyroidism and also in patient with type 2 diabetes mellitus only.Methods: We included in our study 9 type 2 diabetic patients with primary hypothyroidism on stable l-thyroxine replacement doses a...

Background/aim: This study was conducted to determine hyperprolactinemia significance in starting and maintaining sterile inflammation in breast tissue.Methods: We observed 50 patients with nipple discharge syndrome. Patients were divided into clinical group (27 patients with hyperprolactinemia and nipple discharge) and first control group (23 patients with normal serum prolactin and nipple discharge). The second control group included patients from clin...

Objectives: There are reports which suggests that TSH levels are independetly associated with components of metabolic syndrome. The aim of this study was to investigate the relatinship between thyroid stimulating hormone (TSH) and metabolic syndrome (MetS) in owerweight and obese euthyroid subjects.Methods: In 80 euthyroid owerweight and obese subjects, 44 women and 36 man, fasting blood semples were analyzed for glucose, triglycerides and HDL and estima...