Endocrine Abstracts

Introduction: Drug-based therapy is usually the initial treatment for thyrotoxicosis in children, but there is some debate about treatment duration. Our objective was to assess the effect of long-term Carbimazole therapy by block and replacement regime on thyrotoxicosis remission in children.Methods: 15 children with thyrotoxicosis seen in endocrine clinic between January 2006 and January 2010 were included in the audit. Data was collected retrospectivel...

Premature infants are at significant risk of reduced bone mineral content and osteopenia. Inadequate phosphate and calcium uptake in-utero followed by poor postnatal intake in the presence of high growth velocity leads to metabolic bone disease in premature babies. It is not due to vitamin D or parathyroid hormone deficiency.There is no national or international consensus on how to prevent or manage this condition leading to varied practice across the di...

Background: Use of Continuous Glucose Monitoring (CGM) or Flash Glucose monitoring (FGM) has increased in children with type 1 diabetes without a conclusive evidence of sustained improvement in HbA1c. Aims: To assess whether use of CGM/FGM improves HbA1c. To review admissions, complications and impact on the quality of life.Methods: Retrospective study of 33 Type 1 diabetic patients on CGM/FGM. Data collected from the case notes and Twinkle database syst...

Introduction: The management of diabetes during surgery in children is not evidence-based although the ISPAD has produced consensus guidelines.Aims: To explore the variability of guidelines in three regional diabetes networks in South West and South Central England and to compare them to the current ISPAD 2009 Guidelines.Methods: Within an audit of in-patient care, a copy of the surgical guidelines was requested from 27 paediatric ...

Introduction: Thyroxine plays a key role in the development of the structures of the ear, the auditory pathway and in myelination of the central nervous system. The association between congenital hypothyroidism (CH) and neurodevelopmental outcome is clearly established. However, there is a lack of data about the prevalence and severity of hearing loss in the CH population.Methods: Between 1/1/12 and 31/12/13, 187 children were diagnosed with CH and treat...

Background and objective: Adaptive process to hypoxia of altitude involves changes in the homeostatic steady state of several endocrine variables which precede and contribute- to many physiologic adaptations. Physiologic responses to altitude-stress exhibit ethnic variation. However, there has been limited characterization of ‘ethnicity effect’ on endocrine responses to high-altitude stress. This is true for enzyme-immunoassay method (EIA) of plasma hormone analysis....