Endocrine Abstracts

Polycystic ovary syndrome is a common endocrine disorder in women was associated with lipid disorders with increased risk of cardiovascular disease and obesity are associated. This study aimed to compare the lipid profile and fasting plasma glucose levels, insulin resistance in women with polycystic ovary syndrome is done with the control group.Methods: This case–control study on 153 women with PCOS and 449 healthy control subjects from 4 cities in ...

Objective: The purpose of this study was to investigate the incidence of obesity, overweight and Hypertension in children and adolescents aged 10–15 in Ahvaz.Methods: This is a epidemiologic study performed on 176 people aged 10–15 in Ahvaz. In 2009, 300 people underwent weight, height and blood pressure measurements. Five years later, the same people were reassessed for obesity, overweight and hypertension, of whom a total of 176 people agreed...

Objectives: This prospective study aimed at investigating (1) the prevalence of vitamin D deficiency and insufficiency in diabetic adolescents and children in a multi-ethnic cohort, and (2) any association between vitamin D status and ethnic background, glycaemic control (HbA1C), biomarkers of metabolic bone health and lipids.Methodology: Venous blood was drawn from 199 patients with type 1 diabetes (mean age ± SD, 8.2 ± 3.7 years) and 48 patients ...

Objective: To examine different methods of analysing bone health and body composition in children and examine the relationships between these methods.Method: In a LREC approved cross-sectional study, DXA was used to assess bone mineral content (BMC) (at total body (TB), lumbar spine (LS), femur (F) and femoral neck (FN)), cross-sectional moment of inertia (CSMI) at the proximal femur and body composition (defined as Lean mass (LM) and Fat mass (FM)) in 6...

Background: Polycystic ovary syndrome (PCOS) is a common disorder, yet not fully understood. Multiple hormonal and metabolic factors influence the pathophysiology of disease; resulting in various phenotypic characteristics among PCOS population. The luteinizing hormone/choriogonadotropin receptor (LHCGR, OMIM: 152790) is a G protein- coupled receptor mapped on chromosome 2p16.3; its coding region comprises 10 exons separated by 10 introns which transcript to protein w...

IntroductionPolycystic ovary syndrome (PCOS) is a common disorder that is not fully understood. Multiple hormonal and metabolic factors impact on disease pathophysiology resulting in various phenotypic characteristics among the PCOS population. Luteinizing hormone beta subunit (LHβ) (protein ID P01229) is mapped on (chr19p13.3) and consists of three exons. It is specific beta (β) subunit giving to LH from the anterior pituitary its specific fun...

New targeted drug strategies are urgently needed to improve radioiodine uptake and efficiently ablate thyroid cancer cells thereby minimising the risk of recurrent disease. High-throughput screening (HTS) offers a promising approach to identify new candidate drugs that will induce sodium iodide symporter (NIS) function to promote iodide uptake. However, significant progress has been limited by a lack of thyroid cell-based assays amenable to HTS. Here, we constructed a thyroid ...

New combinatorial drug strategies are urgently needed to improve radioiodine (RAI) uptake and efficiently ablate thyroid cancer cells, thereby reducing the risk of recurrent disease. Drug repurposing offers the promise of identifying already approved compounds capable of inducing sodium iodide symporter (NIS) function to enhance iodide uptake. However, a lack of thyroid cell-based assays amenable to high-throughput screening has limited progress. We utilised the mutated yellow...

Case history: A previous healthy 69 year-old female was brought into the ED by her worried husband after he noticed worsening confusion. She developed seizures post arrival to the ED and was admitted under ITU for further care. Retrospective history from the husband indicated she had started feeling unwell around Christmas with a feeling of malaise. She self-medicated with amoxicillin which she had access to as a nurse practitioner. Over the next 2 days she developed headaches...

Introduction: Cushing’s syndrome is broadly categorized into ACTH dependent (pituitary and ectopic source) and ACTH independent (adrenal source). Localizing source of Cushing’s can sometimes be a cumbersome diagnostic process.Case history: A 25-year-old male patient presented with sudden rapid onset weight gain, muscle weakness and occasional headaches.as well as severe dyspnoea, orthopnea and PND. There was no significant past medical or famil...