Endocrine Abstracts

Obesity belongs to the five most important health burdens in modern societies and reaches with ~20% prevalence in Germany epidemic proportions. Obesity significantly increases the risk of developing metabolic (e.g. type 2 diabetes), cardiovascular, orthopaedic, psychologic, and other disorders. Despite the well established epidemiologic relationship between obesity and these co-morbidities, there is a subgroup of metabolically healthy obese patients, which seems to be protecte...

Background: The predictive role of sperm motility and morphology was recently detected in a large sample of more than 20000 assisted reproductive technology (ART) fresh cycles. However, the complete ART procedure consisted in both fresh and frozen-embryos transfers and only a comprehensive evaluation of the entire process could really confirm if these parameters really predict the ART success.Aim of the study: To identify predictive parameters of ART suc...

Lipodystrophy is a rare disease characterized by generalized or partial lack of adipose tissue. Lipodystrophy is associated with leptin deficiency and leads to severe insulin resistance and metabolic abnormalities. A previous literature review reported an estimated prevalence of less than one in a million based on the assumption that only one-fourth of the patients with lipodystrophy may have been reported. Later, the prevalence of lipodystrophy was estimated through a search ...

Introduction: Hypophosphatasia (HPP) is a very rare systemic musculoskeletal disease characterised by low tissue non-specific alkaline phosphatase (ALP). The prevalence of HPP and its associated morbidity in an adult setting is unclear.Methods: A search for serum ALP results less than 36 IU/l within NHS Greater Glasgow and Clyde between 2017 and 2018 revealed 16 280 results. A further search for patients with two ALP <36 separated by 30 days or more ...

Introduction: Congenital hypothyroidism is caused by abnormal development or function of the thyroid gland. Early detection through heel prick screening and treatment prevents irreversible adverse neuro developmental outcome. The national screening program for congenital hypothyroidism in the UK has extremely low false positive rates. We describe 4 siblings with falsely raised TSH related to maternally transmitted macroTSH.Case s...

Yes we need the surgeons but not for all NETs. Due to the implementation of the bowel cancer screening, we have ever been treating more and more small rectal neuroendocrine tumours (NETs). Our data suggested 42% of the NETs we treated was the ones incidentally found in the bowel cancer screening. Current ENET guideline suggested small rectal NETs are good candidates for endoscopic resection provided that complete pathological resection (R0) is obtained and their risk of metast...

Introduction: Therapeutic education (TE) on injection techniques and zooning is a key step for any insulin-treated patient. Our study’s objective was to evaluate the role of ET and the number of sessions required to prevent lipodystrophies (LD).Materials and methods: We conducted a prospective study including any diabetic insulin-treated patient for more than 6 months, followed in our unit between February 2015 and June 2017. Patients responded to a...

Background: Congenital adrenal hyperplasia (CAH) is an autosomal recessive disorder characterised by impaired cortisol synthesis. In the CaHASE study, a surprisingly low number of cases were identified as attending adult endocrine clinics. It has been suggested that patients with CAH are lost to follow up around the time of transition to adult services.In our service, there is a transition clinic that has a lead paediatric and adult Consultant who attend...

Five years after my original post-doc experience overseas, I find myself increasingly contemplating the benefits of that time in my career and whether it was the right decision. Over that same period of time, it’s still clear to me that despite the introduction of a few more research fellowships for the privileged few, the career structure of basic scientists in the UK still appears to be virtually non-existent. So should you consider moving abroad?...

Introduction: Type 1 Kidz is a project, facilitated by Investing in Children CiC, which offers regular group sessions to children and young people living with Type 1 Diabetes and their families across North East England. The aim is to support children and young people to share experiences and stories and learn together to improve their short and long term outcomes. This is supported by a Professional Steering Group.Methods: Monthly or quarterly group ses...