Searchable abstracts of presentations at key conferences in endocrinology

ea0014oc4.3 | Neuroendocriology basis | ECE2007

Absence of germline AIP mutations in early onset sporadic somatotropinomas

Gomes Leonor , Prazeres Hugo , Paiva Isabel , Ribeiro Cristina , Rebelo Olinda , Martins Teresa , Lacerda Manuela , Carvalheiro Manuela

Objective: The pathogenesis of pituitary tumours is still incompletely understood. Somatotropinomas occur both sporadically and in the context of familial syndromes, such as multiple endocrine neoplasia type 1 (MEN1), Carney complex (CNC) and isolated familial somatotropinoma (IFS). Recently, germline mutations were reported in AIP (aryl hydrocarbon receptor interacting protein) gene in Finish and Italian families and in Finish patients with apparently sporadic pituitar...

ea0011p81 | Clinical case reports | ECE2006

Invasive prolactinoma with multiple recurrences: pituitary atypical adenoma or pituitary carcinoma? Report of a case

Gomes L , Paiva I , Ribeiro C , Gomes F , Rito M , Rebelo O , Carvalheiro M

Background: Invasive pituitary tumors may behaviour like some pituitary carcinomas. Although invasiveness is not indicative of malignancy, it probably puts the patient at higher risk of developing a pituitary carcinoma. These are very rare and the diagnosis requires evidence of metastatic disease, either cerebrospinal or extracranial. Although de novo development cannot be excluded they usually present as typical pituitary adenomas, which reveal their malignant characte...

ea0026p229 | Pituitary | ECE2011

Clinical and subclinical apoplexy in nonfunctioning pituitary tumors: clinical features, management and outcome

Gomes Leonor , Paiva Isabel , Ribeiro Cristina , Santos Jacinta , Vieira Alexandra , Alves Marcia , Gouveia Sofia , Saraiva Joana , Rebelo Olinda , Carvalheiro Manuela

Background: Pituitary apoplexy occurs when a tumor undergoes acute hemorrhage, infarct, or both. This often leads to acute severe symptoms (clinical) but can also occur without them and diagnosed on CT/MRI, surgery, pathology (subclinical). To investigate clinical and subclinical apoplexy in nonfunctioning tumors (n=221) from our database.Design: Retrospective review of clinical presentation, tumor characteristics and outcome of 24 patients, 11 fe...

ea0049ep44 | Adrenal cortex (to include Cushing's) | ECE2017

Late-night salivary cortisol: cut-off definition and diagnostic value in Cushing’s syndrome

Lages Adriana , Frade Joao , Paiva Isabel , Oliveira Patricia , Oliveira Diana , Martins Diana , Ventura Mara , Cunha Nelson , Rebelo-Marques Alexandre , Antunes Susana , Leitao Fatima , Carrilho Francisco

Background: The diagnosis of Cushing’s syndrome (CS) remains a challenge in clinical endocrinology. Several screening tests have been proposed to establish hypercortisolism. Late-night salivary cortisol (LNSC) is used as screening tool, however, individualized cut-off levels for each population must be defined.Methods: Three group of subjects were studied: healthy volunteers, suspected CS and proven CS. All patients collected saliva at 23.00 h using...

ea0049ep468 | Diabetes (to include epidemiology, pathophysiology) | ECE2017

Hyperinter study: evaluation of glycemic values in acute inpatients from medical and surgical units. population without diabetes

Goncalves Helena Santos , Paixao Anusca Lopes , Lameirao Cristina , Rafael Ana , Gomes Marta , Silva Rita , Queiros Rita , Lopes Natalia , Rebelo Ana Filipa , Marques Paula Vaz

Introduction: Although inpatients hyperglycemia is a current uneasiness among the medical community, its prevalence in Portugal in unknown. We aim to identify ‘Stress hyperglycemia’ and ‘New onset diabetes’ cases in inpatients in a district hospital.Methods: We evaluated inpatients from Internal Medicine (IM), General Surgery (GS), Orthopedics and Traumatology (OT) and Stoke Unit (SU) departments, admitted from the emergency departmen...

ea0040p21 | (1) | ESEBEC2016

Pituicytoma: a rare tumor

Oliveira Diana , Gomes Leonor , Rodrigues Dircea , Belo Francisco , Rebelo Olinda , Paiva Sandra , Moreno Carolina , Guelho Daniela , Balsa Ana Margarida , Rodrigues Nuno , Cardoso Luis , Martins Diana , Carrilho Francisco

Introduction: Pituicytoma is a low-grade glioma of the suprasellar and sellar regions that is rarely described (about 60 cases described in the literature). The clinical, laboratory and neuroradiological findings are not pathognomonic, and therefore definitive diagnosis is only possible after surgery and histopathological study. Total resection is the treatment of choice, since subtotal removal can often lead to recurrence or progression.Case report: We ...

ea0037ep778 | Pituitary: clinical | ECE2015

Pituicytoma: a rare tumour

Oliveira Diana , Gomes Leonor , Rodrigues Dircea , Belo Francisco , Rebelo Olinda , Paiva Sandra , Moreno Carolina , Guelho Daniela , Balsa Ana Margarida , Vicente Nuno , Cardoso Luis , Martins Diana , Carrilho Francisco

Introduction: Pituicytoma is a low-grade glioma of the suprasellar and sellar regions that is rarely described (about 60 cases in the literature). The clinical, laboratory, and neuroradiological findings are not pathognomonic, and therefore definitive diagnosis is only possible after surgery and histopathological study. Total resection is the treatment of choice, since subtotal removal can often lead to recurrence or progression.Case report: We report th...

ea0022p552 | Neuroendocrinology and Pituitary (<emphasis role="italic">Generously supported by Novartis</emphasis>) | ECE2010

Incidentally found nonfunctioning pituitary macroadenomas: should we suspect them earlier?

Gomes Leonor , Paiva Isabel , Ribeiro Cristina , Santos Jacinta , Vieira Alexandra , Martinho Mariana , Alves Marcia , Gouveia Sofia , Rito Manuel , Belo Francisco , Rebelo Olinda , Carvalheiro Manuela

Background: Nonfunctioning pituitary adenomas are commonly diagnosed as large tumors. Most are detected incidentally during imaging studies. The aim of this study was to evaluate clinical presentation, characteristics and outcome of nonfunctioning pituitary macroadenomas incidentally (NFPMI) discovered.Methods: Twenty-seven patients (mean age 58.9 years, 45–82; 18 males:9 females) with NFPMI were studied. They represent 13.1% of NFPM followed in our...