Endocrine Abstracts

Background: One of the most important complications of the One Anastomosis Gastric Bypass (OAGB) is enterobilioacid reflux (EBAR). We report the concept of the Long Pouch Roux-en Y Gastric Bypass (LPRYGB) meaning a Roux-en-Y with a long pouch and a 100 cm alimentary limb to avoid EBAR, with a long biliopancreatic limb to increase metabolic effects.Methods: A total of 300 LPRYGB cases in a four-year period, with a 90% follow up rate, were analyzed. Anthro...

Diffuse idiopathic pulmonary neuroendocrine cell hyperplasia (DIPNECH) is a relatively recent and rare disease, frequently misdiagnosed. It is characterized as a generalized proliferation of pulmonary neuroendocrine cells and is recognized as a precursor lesion for pulmonary neuroendocrine tumors, although the risk of progression to malignancy is considered low. Here we report a patient with ectopic ACTH-dependent Cushing’s syndrome due to metastatic lung carcinoid tumors...

-Diana Borges Duarte and Francisca Puga are joint first authors and contributed equallyBackground: As therapeutic options improve for Cushing’s disease (CD), most patients can now achieve control or cure of hypercortisolism. However, persistent complaints are often reported. Evaluation of health-related quality of life (HR-QoL) can highlight impairments beyond the stricter clinical aspects. Our aim was to evaluate HR-QoL with a specific focus on men...

Introduction: Prostate cancer is a neoplasm with high incidence and prevalence in the elderly population in western countries. Androgen deprivation therapy (ADT) has been used in locally advanced or metastatic disease, although most relapse, becoming hormone resistant, which is a poor prognostic event.Objectives: The aim of this study was to evaluate the association of genetic polymorphisms NOS2, GPRC6A, VKORC1, ARGI and ARGII in prostate cancer, particu...

Background: The development of a new syringe for lanreotide Autogel, in conjunction with patients, caregivers and HCPs, identified and integrated several upgrades to the previous design that could improve patient care.Aims: To better understand which attributes are pertinent to users, and how user preferences can be optimally assessed, we conducted a systematic literature review of relevant studies of pre-filled devices.Methods: Pu...

Macroprolactin interference is a common problem in the interpretation of immunoassays for prolactin. Identifying macroprolactinemia can prevent errors in diagnosis and subsequent delivery of treatment to patients. The search for macroprolactin through polyethylene glycol (PEG) precipitation followed by percentage recovery is the most common used method in clinical laboratories. This study aimed to evaluate the implementation of macroprolactin assessment in hyperprolactinemic s...

Introduction: Poorly differentiated thyroid cancers are usually aggressive tumors that lack many of the characteristics of differentiated thyroid tissue, including the ability to uptake and process iodine.Case report: A 75-year-old male presented with weight loss, tiredness, asthenia, tremor, increased perspiration, tachycardia and bone pain in several locations. A hard and fixed thyroid nodule was palpable in the left lobe (FNA-«follicular tumor&#1...

Introduction: Long-acting (LA) somatostatin analog (SSA) therapy is a common first-line medical treatment for acromegaly and NETs. There are limited real-world data on patients’ injection experience with the latest LA SSA devices/formulations.Aims: To compare the injection experience of patients with acromegaly or NETs who were receiving treatment with LAN prefilled syringe vs OCT syringe.Methods: A 2021 e-survey of adults wit...

Introduction: Acute Kidney Injury (AKI) is highly prevalent during hospitalization of patients with type 2 diabetes (T2D), and has been associated with increased risk of hypoglycaemia in Intensive Care Units. However, this association in non-critically ill patients is less clear and evidence on the impact of AKI’s severity and duration on hypoglycaemia is lacking.Objectives: To assess the impact of AKI and its severity and duration on the risk of hy...

Introduction: Alemtuzumab is a humanized anti-CD52 monoclonal antibody approved for the treatment of relapsing−remitting multiple sclerosis (RRMS). Through an immune reconstitution mechanism, it leads to thyroid autoimmunity in 35% of cases, with Graves’ disease (GD) being the most common presentation. Alemtuzumab-induced GD exhibits distinctive clinical and immunological features, with rarely reported cases of fluctuating thyroid status with documented both blockin...