Endocrine Abstracts

Iain Robinson, UK AbstractThis prestigious prize is intended for established workers in field of basic and clinical neuroendocrinology, and is generously supported by Ipsen. This year's recipient is Professor Iain Robinson. The prize will be presented as part of the ECE 2010 opening ceremony where Professor Robinson will deliver his lecture. Professor robinson will also deliver two other lectures at fut...

Iain CAF Robinson, National Institute for Medical Research, Mill Hill, London, UK AbstractIain Robinson was born in 1949 and educated at the King Edward VII Grammar School in Sheffield before going to Worcester College, Oxford, to study physiology and medicine. Awarded first class honours in physiology and with medical studies deferred, Iain received an MRC studentship Award for studies on endocrine physiology in the D...

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Sclerostin is an osteocyte-expressed, extracellular cystine-knot protein that is lacking in patients with sclerosteosis, a rare condition characterized by excessive bone formation. Sclerosteosis patients exhibit very high bone mass (lumbar spine Z scores up to +14) and are anecdotally resistant to bone fracture. Homozygous patients commonly develop symptoms associated with cranial nerve entrapment from excessive bone formation but do not show signs of heterotopic bone formatio...

Neuroendocrine cascades regulate essential processes in integrative physiology, such as growth and metabolism, reproduction, and responses to stress. The pioneering work of Geoffrey Harris showed that the pituitary gland, the major endocrine regulator of these processes, is itself controlled by hypothalamic neurones that secrete their products into the hypophysial portal circulation. Intermingling of pituitary cell types and the complex anatomical distribution of the different...

Pituitary growth hormone (GH) is released in a highly pulsatile fashion in response to stimuli from its hypothalamic regulators, GH releasing hormone (GHRH) and somatostatin (SRIF), as well as feedback from peripheral signals. This interplay is complex, and still poorly understood. GHRH is a major factor in controlling pituitary GH synthesis and somatotroph cell number as well as GH secretion, and lack of GHRH or its receptor cause profound somatotroph hypoplasia and dwarfism....

The neuroendocrine cascade regulating episodic growth hormone (GH) secretion plays a central role in post-natal growth and metabolism. Intermingling of GH cells with other pituitary cell types and the complex distribution of the hypothalamic GHRH neurons makes both the cell types difficult targets for selective physical or chemical manipulation. On the other hand, they are excellent targets for physiological transgenesis since their major secretory products derive from highly ...

79 year old male had been admitted due to multiple falls within a space of 24 hours. On admission, he had a full set of bloods which showed hypercalcaemia and no other significant abnormality. His past medical history included Prostate Cancer, Type 2 Diabetes and Urinary retention for which he had a long-term catheter in situ. His current medications were Linagliptin, Apixaban, Bicalutamide and simple analgesia. Initially, he was fluid resuscitated, which seemed to im...

Introduction: A systematic review and meta-analysis undertaken by Bell et al, 2013 found limited evidence to recommend carbohydrate counting as the standard dietary therapy in Type 1 Diabetes (T1DM). There seems to be a gap in current knowledge about comparing carbohydrate counting with other meal planning approaches for children and young people (CYP) with diabetes and the effects on clinical outcomes (Gillespie et al. 1998). Current literature also suggests that the...

A 75 year old male presented in August 2017 with dizziness, nausea and weight loss. In ENT clinic he was found to have right vocal cord lesion. He had CT chest, abdomen and pelvis which showed mediastinal and hilar lymphadenopathy and bilateral adrenal lesions. A PET–CT scan showed intense metabolic uptake in the adrenals with low volume, but moderately active mediastinum and hilar lymphadenopathy. He was presumed to have adrenal and mediastinal Tuberculosis and was start...