Endocrine Abstracts

Introduction: The major clinical importance of 17-OH-Progesterone is related to the diagnosis and therapeutic monitoring of Congenital Adrenal Hyperplasia (CAH). Radioactive assays are widely used in clinical laboratories for measuring 17-OH-Progesterone. The appearance of a non-isotopic, chemiluminescent automatic assay, may be an interesting alternative if the performance of the assay remains the same or higher.Obective: To compare the 17-OH-Progestero...

Introduction: Radioactive assays are widely used in clinical laboratories for measuring free testosterone. The appearance of a non-isotopic, chemiluminescent automatic assay, may be an interesting alternative if the performance of the assay remains the same or higher.Objective: To compare the free testosterone results by radioimmunoassay (RIA) and chemiluminescent assay (CLIA) and to analyze the clinical impact taking into account the % concordance.<...

Introduction: IGF-I is a clinically relevant protein in the diagnosis and monitoring of treatment of growth disorders. The Growth Hormone Research Society and the International IGF Research Society have encouraged the adoption of a universal calibration for immunoassays to improve standardization of IGF-I measurements.Objectives: Comparison of new standardization IGF-I assay with IGF-I assay currently used in CHLC, Lisbon; To study whether the introducti...

Introduction: Anti-TSH receptors (TRAb) are an important marker in the differential diagnosis of the etiologies of hyperthyroidism. They detect serum TSH receptor immunoglobulins that interact with the TSH receptor without the functional discrimination of stimulating from blocking antibodies. A new assay has recently been released, that utilizes recombinant human TSH receptors (hTSHR) for the specific detection and quantification of thyroid stimulating autoantibodies (TSI).</p...

Introduction: There is paucity of data comparing bone densitometry and body composition in adult women with congenital adrenal hyperplasia (CAH) treated with glucocorticoids since childhood and the same parameters in healthy women of the same age and BMI.Methods: 20 women with classical CAH (35% simple virilizing, 65% salt losing), aged 16–45 years, had anthropometric, laboratorial and densitometry exam (DXA) for bone mineral density (BMD) (L1–...

Introduction: Arthropathy affects the majority of acromegalic patients and is a major cause of morbidity, absenteeism and impaired quality of life. GH excess and increased levels of circulating IGFI result initially in a marked thickening of the soft tissues and cartilage. Along with disease progression, there’s subperiostal bone neoapposition, cartilage regressive phenomena and bone structural changes. We aimed to investigate prevalence, clinical presentation, treatment ...

Introduction: Post-surgical hypoparathyroidism is a well known complication of total thyroidectomy. It may occur as transitory hypoparathyroidism that spontaneously recover within a few weeks/months and as permanent hypoparathyroidism needing long-term treatment. Only few cases of hypoparathyroidism newly diagnosed many years after surgery have been reported. We present a patient with hypoparathyroidism that became clinically evident 15 years after the thyroid surgery.<p c...

Energy homeostasis is controlled by neural, endocrine and adipocyte factors and CNS plays a key role in this control. We have previously observed that ovariectomized (OVX) rats treated with estradiol have lower body weight gain associated with an increased hypothalamic CRF mRNA expression. We investigated the role of CRF on activation of hypothalamic CART neurons by leptin in estradiol-treated OVX rats. Female Wistar rats (200–250 g) were subjected to both OVX and cannula...

The wide variability of analysis obtained from the fine needle aspiration cytology (FNAC) of thyroid nodules is attributed to experience differences in their interpretation. It is known that reproducibility is a critical parameter for the clinical usefulness of a diagnostic test. However, interobserver and intraobserver reproducibility of cytological examinations of the thyroid has been very little investigated. We studied 74 patients who underwent FNAC and a thyroidectomy. Th...

Background: Assessment of response to therapy is a valid tool for dynamic risk stratification in patients with differentiated thyroid cancer (DTC). It is well documented in patients treated with total thyroidectomy and radioiodine ablation therapy (RAI), but data is still sparse regarding patients treated with lobectomy. Our study aimed to evaluate response to therapy in patients with DTC treated with lobectomy.Methods: We performed a retrospective study...