Endocrine Abstracts

Unfortunately diabetes is a growing problem with now more than 537 million people worldwide having diabetes according to International Diabetes Federation. Excess morbidity and mortality in diabetes is related to the development of diabetic kidney disease seen in 30-40%, which not only causes end stage kidney disease, but also increases risk for cardiovascular events and mortality, which is the leading cause of death. Treatment of diabetic kidney disease has been control of gl...

Hypertension is a major risk factor in type 2 diabetes both for cardiovascular and microvascular complications. It has been estimated that hypertension contributes to 41% of the attributable risk for mortality. Proper assessment of blood pressure, consideration of diurnal pattern, white coat and masked hypertension is important. Lifestyle factors should be addressed in the management, but in most patients pharmaceutical intervention is needed. The optimal intervention usually ...

Aims: To study the potential long-term impact of a 7.8 years intensified, multifactorial intervention in patients with type 2 diabetes mellitus and microalbuminuria in terms of gained years of life and years free from incident cardiovascular disease.Methods: The original intervention (mean treatment duration 7.8 years) involved 160 patients with type 2 diabetes and microalbuminuria that were randomly assigned to either conventional therapy or intensified...

Background: There are differences in the development of diabetic nephropathy (DN) between men and women but the underlying molecular mechanisms are unknown. The urinary proteome may contain sex-specific biomarkers and thereby identify differentially regulated pathways to DN in men and women.Method: Urine samples were obtained from 157 patients with type 2 diabetes (age, 61 (29–71) years; 120 men and 37 women), preserved renal function (eGFR, 88 &#17...

Head and neck paragangliomas (HNPGLs) are a type of neuroendocrine tumour. They arise from the sympathetic ganglia and can be either sporadic or due to hereditary syndromes (up to 40%). Most HNPGLs do not produce significant amounts of catecholamines1. Often, HNPGLs are detected in late stages due to compression or infiltration of cranial structures1. We report a case of a paraganglioma of the basis cranii due to somatic variants of SDHB (succinate dehydr...