Searchable abstracts of presentations at key conferences in endocrinology

ea0038p305 | Pituitary | SFEBES2015

In vitro effects of Imatinib on somatotrophinoma cell line

Gupta Prakamya , Rai Ashutosh , Sachdeva Naresh , Radotra Bishan Das , Bhansali Anil , Mukherjee Kanchan Kumar , Hota Debashish , Korbonits Marta , Dutta Pinaki

Introduction: Acromegaly is a neuroendocrine disorder caused by excessive secretion of growth hormone (GH). Current treatment includes surgery, radiotherapy and drugs like somatostatin or dopamine receptor agonist. In spite of combination of therapies cure rate is dismal. There is a quest for new therapeutic targets with optimal efficacy, least side effect without any cost constraints. Recently, a few reports have shown that tyrosine kinase inhibitor (Imatinib) causes growth f...

ea0024p9 | (1) | BSPED2010

Classical CAH due to a rare compound heterozygote mutation masquerading as pubarche in a 3 years old girl

Sachdev P , Dane C , Natarajan A

Background: Congenital adrenal hyperplasia, (CAH) is a common autosomal recessive condition, 95% of which is attributable to mutations in the 21-hydroxylase (CYP21) gene. There is a wide range of clinical features and genotype phenotype correlations for common mutations are well described.Case: EG presented to the endocrine clinic at the age of 3.5 years with pubarche of 6 months duration and Tanner staging of PH3, B1and clitoromegaly (Prader stage 1) Ur...

ea0066p66 | Learning from Mistakes and Miscellaneous | BSPED2019

β-carotenaemia with secondary amenorrhea in a teenage athlete

Thurston Victoria , Calvert Jennifer , Sachdev Pooja

Introduction: Aurantiasis cutis is an asymptomatic condition characterised by yellow discolouration of the skin and is caused by high levels of β-carotene. Beta carotenaemia has frequently been associated with the development of menstrual disturbances in women but no causal link has been established.Case report: We herein present a case of a 15 year old Caucasian girl (otherwise well, BMI 24) who presented with aurantiasis cutis together with a four...

ea0023p18 | (1) | BSPED2009

Current use of the Synacthen Test: A questionnaire survey of British Paediatric Endocrinologists

Sachdev Pooja , Wright Neil , Elder Charlotte

Background: Over the last two decades, supported by two metanalyses, the low-dose Synacthen Test (LDST) has gained in popularity, with many believing it to be more sensitive than the supra-physiological Standard (250 microgram) Short Synacthen Test (SSST). The literature reveals lack of consensus about its specific clinical applications, what is considered “low-dose” and how that dose is made up.Methods: To ascertain current UK practice,...

ea0017p26 | (1) | BSPED2008

The solution for salt Wasters: should we take it with a pinch of salt?

Sachdev P , Persaud J , Plunkett MCB

Salt solutions are routinely used in salt losing conditions like congenital adrenal hyperplasia, pseudohypoaldosteronism, cystic fibrosis and polyuric salt wasting kidney disease. Problems with administration (of a liquid to an increasingly solid diet), compliance and the behavioural impact of altering food preferences abound.We describe the case of a 2-year-old boy DA with aldosterone synthetase deficiency who is currently on fludrocortisone and sodium ...

ea0008p6 | Clinical case reports | SFE2004

A young woman presenting with multiple bone swelling, deformities and fractures

Chattopadhyay A , George R , Kapur V , Sachdev A

A 35 year old woman presented with severe bone pain, body aches, progressive deformities of chest, skull and swelling of hands for two years. Past history included bilateral total hip replacement for fracture of neck of femur one year back. She was normotensive and normo-glycemic. Her dietary consumption of calcium and vitamin D and sun-exposure was adequate. Investigation revealed haemoglobin 5.4gram per deciliter. Serum calcium and serum iPTH levels were elevated at 3.6milim...

ea0095oc5.4 | Oral Communications 5 | BSPED2023

A survey of current clinical care of children and young people with Klinefelter Syndrome in United Kingdom

Chandwani Manju , Jeevarathnam Dhivyalakshmi , Sachdev Pooja

The European Academy of Andrology (EAA) published the first consensus guideline on KS in 2021 to standardise the care provided to patients with Klinefelter Syndrome (KS) in various developmental stages. We conducted an online national survey advertised in the British Society of Paediatric Endocrinology and Diabetes newsletter (BSPED) to evaluate clinical care provided to children and young people (CYP) with KS. The survey ran over a period of 4 months (January-April 2023). We ...

ea0095p85 | Adrenal 2 | BSPED2023

Single-centre experience of the use of anastrozole in prepubertal boys with advanced bone age

Kamaleldeen Eman B , Sachdev Pooja , Law James

Background: Aromatase inhibitors block the aromatization of androgens to oestrogen. They are used off-label to delay bone maturation where bone age (BA) is advanced secondary to androgen excess. Side effects include hair loss, headache, decreased appetite, bone pain, drowsiness, and osteoporosis. There is limited data on Anastrozole’s safety in paediatrics. We report our experience (Anastrozole 1 mg OD) in 4 pre-pubertal boys with advanced BA.<p class...

ea0077p92 | Neuroendocrinology and Pituitary | SFEBES2021

Age- gender- and tanner stage-specific reference intervals for serum insulin-like growth factor binding protein 3 (IGFBP-3) and the insulin-like growth factor I (IGF-I) to IGFBP-3 molar ratios in healthy school children of a north indian city

Ravi Teja KV , Marwaha RK , Malhotra Bhanu , Sachdeva Naresh , Das Liza , Rastogi Ashu , Mukherjee Soham , Sharma Sadhna , Verma Neelam , Malhotra Sunita , Bhansali Anil , Bhadada Sanjay , Pal Rimesh , G Dewan , Monaghan Phillip , Trainer Peter , Korbonits Marta , Dutta Pinaki

Context: Serum IGF-binding protein-3 (IGFBP-3) and molar IGF-I to IGFBP-3 ratio can aid the diagnosis of GH-related diseases. However, their clinical utility is limited by lack of validated reference intervals.Objectives: To establish age-, gender- and Tanner stage-specific reference intervals for IGFBP-3 and IGF-I to IGFBP-3 ratio for Indian ethnicity.Setting and Participants: We conducted a cross-sectional epidemiological study (...

ea0077p223 | Neuroendocrinology and Pituitary | SFEBES2021

Generation of normative data on serum insulin-like growth factor I (IGF-I) in healthy school children of a north indian city

Dutta Pinaki , Teja KV Ravi , Aggarwal Arun , Sachdeva Naresh , Malhotra Bhanu , Das Liza , Walia Rama , Rastogi Ashu , Bhansali Anil , Bhadada Sanjay , Pal Rimesh , G Dewan , Marwaha R K , Monaghan Phillip , Trainer Peter , Korbonits Marta

Context: To diagnose and monitor GH-related disorders, serum IGF-I is a cornerstone, but Indian ethnicity based data, following consensus criteria for establishment of normative data are not available.Objectives: To generate normative IGF-I data for chronological age, bone age (BA) [Greulich & Pyle] and Tanner stage for both genders.Setting and Participants: We conducted a cross-sectional epidemiological study for children (age...