Searchable abstracts of presentations at key conferences in endocrinology

ea0011p28 | Bone | ECE2006

Evidence for high prevalence of hormonal irregularities in male osteoporosis

Goebel S , Riegel C , Seefried L , Saller B , Jakob F

Introduction: Osteoporosis in males is an underdiagnosed condition. It is considered to be of secondary pathogenesis in up to 60% of cases. In order to establish rational flow charts for the diagnosis and management of osteoporosis in men solid data seem to be necessary about the incidence of certain underlying diseases.Methods: In a prospective screening for hormonal alterations we analysed 65 patients with male osteoporosis according to laboratory para...

ea0016p386 | Neuroendocrinology | ECE2008

Isolated GH deficiency of adult-onset in the KIMS database: prevalence, clinical presentation, and response to GH replacement

Casanueva Felipe , Abs Roger , Popovic Vera , Koltowska-Haggstrom Maria , Jonsson Bjorn , Saller Bernhard , Kourides Ione

Of the ~12 500 GH treated subjects with adult-onset GH deficiency (GHD) in KIMS (Pfizer International Metabolic Database), 3744 with multiple pituitary hormone deficiencies (MPHD) and 367 (9%) with isolated GHD (iGHD) were eligible for baseline analysis. Subjects met the following inclusion criteria: 1) never received GH prior to entry in KIMS, 2) had stimulation tests with insulin or glucagon (GH<3 μg/l), arginine (GH<0.4 μg/l), or arginine+GHRH (cut-offs ba...

ea0016p404 | Neuroendocrinology | ECE2008

Total and cause-specific mortality in patients from the KIMS database: direct evidence for a beneficial effect of GH replacement therapy on mortality in adult GH deficient patients

Mattsson Anders , Koltowska-Haggstrom Maria , Saller Bernhard , Wilton Patrick , Gaillard Rolf

Growth hormone (GH) replacement in adults with severe GH deficiency (GHD) has well established beneficial effects on the cardiovascular risk profile. Whether this is associated with reduced mortality is still unclear. The present study addresses this question by analysing mortality data in KIMS (Pfizer international metabolic database) and is based on 9610 patients (47% females), accumulating 37882 patient-years of follow-up. There were 257 recorded deaths against 255.1 expect...

ea0011p511 | Endocrine tumours and neoplasia | ECE2006

The latest safety and efficacy data of patients treated with Pegvisomant

Schreiber I , Forssmann K , Buchfelder M , Droste M , Mann K , Saller B , Strasburger CJ

The German Acrostudy is at present the largest database on acromegalics (n=184) treated with pegvisomant (Somavert®). 91% pts underwent pituitary surgery, 45% received radiation therapy, and previous medical therapy included dopamine agonists (56%), octreotide (90%) and/or lanreotide (10%). Common concomitant diseases at baseline were hypertension (47.0%), diabetes mellitus (31.7%), and gallstone disease (25.6%). Efficacy analysis was performed in 134 pt...

ea0011p613 | Neuroendocrinology and behaviour | ECE2006

Quality of life (QoL) and psychiatric sequelae following aneurysmal subarachnoid hemorrhage (SAH): Does neuroendocrine dysfunction play a role?

Kreitschmann-Andermahr I , Poll E , Saller B , Reineke A , Gilsbach JM , Hütter BO

QoL is an important outcome criterion in clinical research and is used to monitor treatment effects. Patients who have sustained SAH oftentimes have impaired QoL as do patients with untreated hypopituitarism. Considering the high degree of partial hypopituitarism in SAH survivors, we sought to elucidate the impact of neuroendocrine dysfunction on QoL and the prevalence of psychiatric sequelae in these patients.QoL, depression and symptoms of posttraumati...

ea0014p452 | (1) | ECE2007

Structured assessment of neuroendocrine dysfunction following traumatic brain injury and aneurysmal subarachnoid hemorrhage – the interdisciplinary German database

Kreitschmann-Andermahr Ilonka , Schneider Harald , Buchfelder Michael , Saller Bernhard , Koenig Eberhard , Jordan Martina , Stalla Günter

The results of recent studies indicate that traumatic brain injury (TBI) and aneurysmal subarachnoid hemorrhage (SAH) must be considered as frequent causes of long-term disturbances of hypothalamo-pituitary function. Indeed, partial hypopituitarism has been established with a pooled frequency of 33% in TBI and of 48% in SAH survivors. Nevertheless, still little is known about risk factors and clinical characteristics of pituitary impairment after these two types of brain damag...

ea0016p425 | Neuroendocrinology | ECE2008

Tests of growth hormone (GH) status in severe GH deficiency: do they identify a similar phenotype? Insight from the KIMS database

Toogood Andrew , Brabant George , Buchfelder Michael , Feldt-Rasmussen Ulla , Koltowska-Haggstrom Maria , Jonsson Bjorn , Krogh Rasmussen AEse , Maiter Dominique , Saller Bernhard , Biller Beverly

A GH peak of 3 μg/l during the insulin tolerance test (ITT) is considered the gold standard for identifying adults with severe GH deficiency. Alternative stimuli such as arginine (AST) and glucagon (GST) are also employed but produce lower GH peaks than the ITT in normal subjects. Despite this, 3 μg/l is used as the diagnostic threshold for these tests, raising the possibility that severe GH deficiency is being diagnosed inappropriately.We stud...

ea0026p216 | Pituitary | ECE2011

Long-term treatment of acromegaly with pegvisomant (Somavert): cross-sectional observations from ACROSTUDY, a post-marketing, international, safety, surveillance study

van der Lely A J , Lundgren F , Biller B M K , Brue T , Cara J , Ghigo E , Hadavi J Hey , Rajicic N , Saller Bernhard , Sanocki John , Strasburger Christian , Webb Susan , Haggstrom Maria Koltowska

Introduction: Somavert is a GH receptor blocker, which inhibits hepatic production of IGF1. While it has been approved for the treatment of acromegaly since 2003 there are few data regarding its effects in everyday clinical practice.Methods/design: ACROSTUDY is an open-label, international, prospective, non-interventional, post-marketing surveillance study monitoring the long-term safety and efficacy of Somavert.Results: As of Dece...

ea0016oc1.1 | Neuroendocrinology and pituitary | ECE2008

Structured assessment of neuroendocrine dysfunction following traumatic brain injury and aneurysmal subarachnoid hemorrhage in 921 patients: the German Interdisciplinary Database

Schneider Harald , Schneider Manfred , Tuschy U , Wallschofski Henri , Faust Michael , Renner C , Kopchak Anna , Jordan Martina , Saller Bernhard , von Rosen Friedrich , Kreitschmann-Andermahr Ilonka , Buchfelder Michael , Stalla Gunter Karl

Background: Recent studies show that traumatic brain injury (TBI) and aneurysmal subarachnoid hemorrhage (SAH) are frequent causes of long-term disturbances of hypothalamo–pituitary function. Still little is known about risk factors and clinical characteristics of pituitary impairment after brain damage. This study aimed to address these questions on a larger scale by establishing a national registry of these patients.Methods: All centers treating p...