Searchable abstracts of presentations at key conferences in endocrinology

ea0029p531 | Diabetes | ICEECE2012

Conserved mitochondrial coupling and adaptive substrate control in inuit and caucasians: acclimatization to active life styles in the arctic winter

Boushel R. , Saltin B. , Gnaiger E.

Mitochondria oxidize food substrates to generate energy for cellular work and heat is variably generated depending on the degree of coupling of electron transport to oxidative phosphorylation (OXPHOS). It has been hypothesized that climatic pressures exerted selection for mitochondrial haplogroup in arctic populations for a lower coupling of mitochondrial respiration to ATP production in favor of heat production. In this study muscle mitochondrial function was studied in Inuit...