Endocrine Abstracts

Background: Many testosterone (T) formulations are now available for treating male hypogonadism. Intramuscular injectable T esters and transdermal T gel are the most commonly used in clinical practice. Transdermal T gel is often preferred by patients due to ease of use and reduced fluctuations in serum T compared to injectable esters. A daily dosage of 20 mg – 80 mg mimicking circadian profile is recommended to adequately treat hypogonadal men.Aim: ...

Background: Hypovitaminosis D represents at present a worldwide public health problem. Recent studies have demonstrated the pleiotropic effects of vitamin D, in addition to its known actions on calcium-phosphorus metabolism. Among the several non-skeletal effects, a potential anti-inflammatory and immunomodulatory action has been suggested. Vitamin D deficiency has been reported in several chronic conditions associated with increased inflammation and deregulation of the immune...

Aim: To assess the relation between questionnaires of androgenic function (AMS and IIEF-EF scores) and sex hormones (DHT, estradiol and total and free testosterone) in men attending an outpatient clinic for endocrine and reproductive disorders.Methods: We retrospectively reviewed all data entered in the electronic database of the Münster Center of Reproductive Medicine and Andrology (CeRA) Androbase from patients visited between January 2015 and Oct...

Introduction: Physical exercise exerts several effects on endocrinological homeostasis and, in particular, sprint exercise elicits the largest testosterone response per unit of work, while in response to prolonged endurance exercise testosterone levels will typically decline. In contrast to a large amount of paper about the modification of testosterone during physical exercise few study evaluated how DHT was influenced by a single bout of aerobic exercise.<p class="abstext...

Hypogonadism occurs in myotonic dystrophy (DM) type 1 and 2, a multisystemic autosomal dominant disorder. DM patients have genetically induced insulin-resistance (IR) and visceral obesity, providing a model to study the impact of metabolic disruptions on hypogonadism. We assessed hypothalamic-pituitary-gonadal function and metabolic features in 22 DM1 and 8 DM2 males (mean±S.D., 46±11years). Hypogonadism, defined as total testosterone (T)<320 ng/dl...

Background: The FSHB –211 G > T single nucleotide polymorphism (SNP) is known to affect pituitary FSH output by reducing the transcriptional activity of FSHB. Identifying the response of the pituitary to exogenous GnRH stimulation in subjects with FSHB -211 G > T SNP could provide useful information concerning the mechanisms regulating FSH synthesis and release.Objectives: This study aimed to assess the pituitary...

Introduction: Myotonic dystrophy (DM) type 1 and 2 are multisystemic autosomal dominant disorders with visceral obesity, insulin resistance and hypogonadism. The prevalence of metabolic risk factors for coronary artery disease (CAD) in DM is not well defined, particularly in patients affected by DM2, a milder and clinical challenging condition.Methods: We assessed the frequency of CAD risk factors in 31 male DM1 (44±11 years) and 13 male DM2 (54&#17...

Introduction: Hypogonadism occurs in myotonic dystrophy (DM) type 1 and 2, a multisystemic autosomal dominant disorder with insulin resistance and visceral obesity. DM patients provide a model to investigate the impact of metabolic alterations on hypogonadism.Methods: We assessed Leydig and Sertoli cell functions and metabolic features in 32 DM1 (44+11 years),13 DM2 patients (54+9 years) and 32 age and BMI-matched controls.Results:...

Thyroid associated ophthalmopathy (TAO) is a chronic autoimmune disorder characterized by an increased volume of the adipose/connective tissue in the human orbit. Fibroblasts from the connective orbital tissue are able to differentiate into mature adipocytes if grown in particular culture conditions. Aim of the present study was to determine the gene expression profile of orbital fibroblasts after adipocytic differentiation. Fibroblasts in primary culture were obtained from or...

Background: Varicocele repair is often suggested to improve reproductive outcomes, but there is no clear indications on which subjects are more likely to benefit from treatment. We assessed spermatogenetic and endocrine function of the testis in a population of young subjects with a 12-month follow-up following percutaneous treatment.Methods: We retrospectively reviewed data from 77 young patients (mean age 23.3 years, range 18–35) followed in our c...