Endocrine Abstracts

Metabolic syndrome (MS) is associated with a two-fold increase in risk of cardiovascular disease and a five-fold increase in risk for diabetes.The aim of our study was to determine the prevalence of MS in patients with Type 1 diabetes using the latest IDF criteria and evaluate any correlation between MS and daily insulin dosage.Seventy-five patients (44 males, 31 females; mean age 43 years; age range 19–73 years) with type 1 d...

Introduction: It is recognised that osteocytes, by secreting sclerostin plays a more central role in bone homeostasis. Sclerostin is a physiological inhibitor of bone formation. By binding to the LRP5/6 receptor sclerostin inhibits the Wnt signalling pathway. A cross-sectional study was undertaken to ascertain whether an endogenous sclerostin circadian rhythm exists in healthy individuals.Subjects and methods: Six healthy young men with normal BMD were a...

Introduction: Osteotropic hormones demonstrate circadian rhythms which are integral to bone homeostasis. Sclerostin is a physiological inhibitor of bone formation. We have established that Sclerostin has a distinct circadian rhythm with a nocturnal peak. Analysis was performed to determine the relationship of Sclerostin levels to PTH, Calcium, Phosphate, βCTX and P1NP in healthy young men.Methods: Six healthy young men with normal BMD were admitted ...

Introduction: A joint RAI clinic, led by an endocrinologist and nuclear physicist, was introduced in our centre, in July 2007.Aims: To compare our practice since the introduction of the joint RAI clinic against guidelines from the Royal College of Physicians of London.Methods: A retrospective audit of patients who received RAI, Sept 2007–Oct 2008. Data collected from patients’ case notes and compared to previous audit 200...

Diabetes prevalence has been worryingly growing in recent decades, reaching pandemic proportions. Genetic and environmental factors play a role in diabetes aetiology. While the genetic background may predispose individuals to the disease, environmental factors, including exposure to chemical pollutants that can disrupt metabolic functions (also known as metabolism disrupting chemicals or MDCs), may act as triggers to diabetes development. Despite growing evidence suggesting a ...

Women with polycystic ovary syndrome (PCOS) have higher prevalence of metabolic disturbances such as changes in lipid profile, diabetes, hypertension and metabolic syndrome. Variants on vitamin D receptor (VDR) gene have also been related to metabolic comorbidities in general population. Therefore, the aim of the present study was to investigate whether Apa-I polymorphism (rs7974232) in the VDR gene is associated with metabolic syndrome and endocrine profile in PCOS. In this c...

Introduction: Neonatal diabetes mellitus (NDM) is a rare disease diagnosed within the first months of life that is usually permanent in 50% of cases. Heterozygous mutations of KCNJ11 and ABCC8 genes encoding the two Kir6.2 and SUR1 subunits of the b-cell ATP-dependent potassium channel have been associated with NDM, which is characterized by a successful response to sulfonylureas.Case report: We present a 32-year-old woman diagnosed wit...

Introduction: Generously supported by IPSEN)-->Dopamine agonists (DA) effectively normalize prolactin secretion and reduce tumour size in most patients with macroprolactinomas. However, some patients are considered partially/totally resistant. Some authors propose that patients treated for 2 years, with normal prolactin secretion with low dose AD and maximal tumour diameter reduction >50%, could suspend treatment, but relapse rat...

Generously supported by IPSEN)-->Insulin and somatotropin (GH) have opposite effects in glucose metabolism. GH increases the production of glucose through lypolisis and inhibits hepatic and peripheric neoglucogenesis induced by insulin. When insulin secretion is insufficient to overcome insulin resistance, intolerance to glucose or diabetes appears. Drugs used in the treatment of acromegaly also influence glucose metabolism: SSA decr...

Introduction: In 1960, Van Wyk and Grumbach described the association of hypothyroidism and precocious puberty. Hypothyroidism leads to delayed bone age and a reduction in growth rate by reducing the amplitude of GH pulses. When precocious puberty is associated with thyroid hypofunction, estrogen action on the epiphyseal plates reduce this delay. We report the case of a child who developed incomplete puberty and reduced growth rate, caused by primary hypothyroidism.<p clas...