Endocrine Abstracts

Aim: Sibutramine, orlistat and metformin appear beneficial for the treatment of adult with obesity. Several investigators have suggested that larger weight losses might be achieved by combining weight loss agents. The aim of this study was to compare the effectiveness of sibutramine monotherapy versus sibutramine plus metformin combination therapy in obese women with normal glucose tolerance.Material-method: This is a 6 month, prospective and randomized ...

Constitutive activation of the cAMP pathway by activating TSHR mutation stimulates both thyrocyte proliferation and function. Thus they lead to formation of toxic thyroid nodules (TTNs) and ultimately hyperthyroidism. The in vitro activity of the various TSH-receptor mutation varies from 2–7 fold cAMP increase over the wild type TSH receptor. One previous study invrestigated a possible genotype to phenotype relation in TTNs with somatic TSHR mutation with a negativ...

The association of thymoma with myasthenia gravis is well known, however association of these two syndromes (Thymoma+Myasthenia gravis) with Addison’s disease is very rare. In here we report myasthenia gravis and autoimmune Addison’s disease in a patient with thymoma.A 32-year-old man was admitted to our hospital with symptoms of weakness, anorexia, nausea, vomiting, pigmentation of skin and mucous membranes for 2 years. He had undergone to the...

Objective: 21 different activating germline mutations have been identified up to date. We describe a large euthyroid family with a new TSH-receptor(TSHR) germline mutation where the hyperthyroid index patient also carries a somatic TSHR mutation.Method: Mutation analysis of the exon 9 and 10 of the TSHR gene from the peripheral blood samples of the members of this family and toxic thyroid nodules of the index patient were performed by denaturing gradient...

Objective: Differences in iodine intake could account for the variable prevalences reported for somatic TSHR and Gs alpha mutations in TTNs. However, this question has never been setteled, since no study has yet determined the TSHR mutation prevalence in TTNs in regions with and without iodine deficiency in the same population. Therefore we studied the prevalence of somatic TSHR mutations in TTNs by investigating TTNs from patients who lived in endemic and nonendemic goiter re...

Objective: Gestational diabetes mellitus (GDM) is strongly associated with maternal obesity. Omentin-1 is secreted from the adipose tissue and enhances insulin action. Circulating levels are inversely correlated with body weight, decreased in type 2 diabetes. Pre-existing maternal obesity has been shown to be associated with lower omentin-1 expression in placenta, adipose tissue and maternal plasma. In our previous study, we had shown that plasma omentin-1 level is decreased i...

Objective: Irisin is a novel adipomyokine that regulates the differentiation and phenotype of adipose tissue. It induces an increase in total body energy expenditure, improves insulin sensitivity, and glucose tolerance. It showed that the levels of irisin are low in obese, diabetic and impaired glucose tolerance patients. However, the information of the levels of circulating irisin in gestational diabetes mellitus (GDM) is controversial. In this study, we investigated i) the l...

Introduction: Accumulating evidence indicate that high PTH resulting from primary or secondary hyperparathyroidism, is associated with hypertension, insulin resistance, dyslipidaemia, obesity, and cardiovascular mortality. Here, we aimed to show whether high PTH levels in obese population contribute the metabolic complications of obesity.Methods/design: The medical records of all subjects attending the obesity outpatient clinic of Kartal Dr Lutfi Kirdar ...

Surveys for the assessment of the iodine status, carried out between 1997 and 1999 in Turkey showed that the country was severe to moderately iodine deficient. (National median UIC 36 μg/l, goiter prevalence % 31.8). Therefore, a national IDD control program had been implemented and mandatory salt iodization were applied by July 1999 with 50–70 mg/kg KI or 25–40 mg/kg KIO3 to the household salt.Objectives: To evaluate the curren...

Objectives: Assessment and monitoring which are two major components of a sustainable programme to eliminate IDD is being performed in Turkey since 1997. The initial survey, for the assessment of the iodine status, carried out between 1997 and 1999, showed that the country was severe to moderately iodine deficient (national median UIC: 36 μg/l, goiter prevalence % 31.8). Therefore, a national IDD control program had been implemented and mandatory salt iodization were appl...