Endocrine Abstracts

Aim: We previously reported preliminary evidence that use of TRH with CRH during inferior petrosal sinus sampling (IPSS) in Cushing’s syndrome gave additional information about quality of pituitary venous sampling and significance of gradients. We now report long-term experience of this technique in 40 patients investigated 1993–2005. We used standard central:peripheral ratios (C:P) of 2:1 basally and 3:1 after stimulation to indicate pituitary secretion and intersin...

Retrospective audit of Patients had Parathyroidectomy over 2 years in East Sussex NHS trust; 73 patients had Parathyroid surgery for Primary hyperparathyroidism during this period. We have collected the data using case notes and hospital electronic records. Fifty-six patients were females and 17 were Males. Ninety-three per cent of patients were more than 50 years old. Common presenting symptoms were Lethargy (51%), bone pain (44%) and other symptoms were polyuria, polydipsia....

Back ground: Our Cortisol assay was changed from older generation assay to new second-generation Roche cortisol assay for the Short synacthen tests. There is ~ 20–25% difference in cortisol values between these assays. There are debates about the cut off values for normal response (cortisol of 420 or 440 nmols), compared to 550 nmols/l with older assay. And to assess the use of 30 and 60 min cortisol response.Methods: Short synacthen tests data were...