Endocrine Abstracts

Introduction/objective: The exact mechanism of autoimmune thyroid destruction in patients with Hashimoto’s thyroiditis (HT) remains unclear. Recently it has been found that the HT patients demonstrate increased levels of anti-DNA antibodies, which may be directed against various nuclear structures and may be involved in process of apoptosis. In this study, we examined the potential association between anti-DNA antibodies levels, thyroid function and activity of autoimmune...

The mechanism of autoimmune destruction of thyrocytes in pathogenesis of Hashimoto thyroiditis remain unclear. It has been showed that the HT patients produce antibodies to DNA, which are directed against various structures of the nucleus and probably may be involved in process of apoptosis.In order to show that the increased production of anti-DNA antibodies is intrinsic property of HT, but not of another non-autoimmune thyroid diseases, we have measure...

Hereditable forms account for 30–40% of pheochromocytomas (pheo). The role of germ-line mutation of VHL, RET, SDHB, SDHD gene has been largely elucidated. However, genotyping a group of 172 sporadic or familial pheo, we have characterize five unrelated probands with familial pheo without any sequence variants of RET (7 exons), or of the entire coding sequence of VHL, SDHB, SDHC or SDHD.The proband #1 had a bilateral pheo when 32 and a local recurren...