Searchable abstracts of presentations at key conferences in endocrinology

ea0050pl2 | Clinical Endocrinology Trust Lecture | SFEBES2017

Mechanisms underpinning human insulin resistance

Savage David

Adipose inflammation is increasingly percieved to be a major factor in the pathogenesis of obesity associated insulin resistance. However, human evidence supporting this hypothesis remains largely unconvincing. An alternative model is suggested by observations made in patients with rare forms of lipodystrophy; namely that a relative inability to cope with sustained surplus energy intake underpins insulin resistaance. Recent data suggesting that subtle forms of lipodystrophy ar...

ea0050pl2 | Clinical Endocrinology Trust Lecture | SFEBES2017

Mechanisms underpinning human insulin resistance

Savage David

Adipose inflammation is increasingly percieved to be a major factor in the pathogenesis of obesity associated insulin resistance. However, human evidence supporting this hypothesis remains largely unconvincing. An alternative model is suggested by observations made in patients with rare forms of lipodystrophy; namely that a relative inability to cope with sustained surplus energy intake underpins insulin resistaance. Recent data suggesting that subtle forms of lipodystrophy ar...

ea0019s80 | (1) | SFEBES2009

Magnetic resonance spectroscopy: a window into carbohydrate and lipid metabolism

Savage David

Although abnormal glucose metabolism defines type 2 diabetes mellitus (T2DM), efforts to understand the pathogenesis of T2DM are increasingly focused on disordered lipid metabolism. Magnetic resonance spectroscopy (MRS) is a non-invasive technique which provides real time data. Its uses in metabolic studies include: 1) static measurements of energy stores e.g. intramyocellular and hepatic glycogen and triglyceride levels and, 2) dynamic measures of mitochondrial function (ATP ...

ea0011s99 | Metabolic syndrome | ECE2006

Insulin resistance and type 2 diabetes – insights from the study of extreme human phenotypes

Savage DB

Insulin resistance, which can be defined as a state of reduced responsiveness to normal circulating levels of insulin, plays a major role in the development of type 2 diabetes. Whilst standard definitions of insulin resistance still define it in terms of insulin’s effects on glucose metabolism, the last decade has seen a shift from the traditional ‘glucocentric’ view of diabetes to an increasingly acknowledged ‘lipocentric’ viewpoint. This hypothesis h...

ea0056s20.1 | All you need to know about lipodystrophy (Endorsed by Endocrine Connections) | ECE2018

Lipodystrophy as a model for prevalent insulin resistance

Savage David

All forms of severe lipodystrophy are associated with features of the metabolic syndrome including insulin resistance, T2DM, NAFLD, dyslipidaemia and cardiovascular disease. The question I will address is if this means that what happens in patients with monogenic forms of lipodystrophy is at all relevant to common forms of insulin resistance and the metabolic syndrome....

ea0005s50 | Alternative Careers for Endocrine Researchers | BES2003

Research for clincial paediatric endocrinologists

Blair J , Savage M

Few Paediatric Endocrinologists seek alternative careers on completion of subspeciality training. In addition to developing optimal clinical services, however, opportunities exist to work at the interface of clinical medicine and basic scientific research. Exciting developments in the investigation, diagnosis and treatment of paediatric endocrine patients reflect the success of collaboration between basic scientists and clinicians, paediatricians and adult physicians.Short...

ea0050ep050 | Clinical Biochemistry | SFEBES2017

Starvation ketoacidosis – a rare but significant metabolic condition

Nardeosingh Siddarth , Savage Amy , Banerjee Moulinath

Diabetic ketoacidosis and pregnancy related ketoacidosis are the most common forms of ketoacidosis seen in acute medical units. We describe here two rare cases of starvation ketoacidosis.Case 1: 63 years old gentleman with no history of diabetes, presented with persistent vomiting for 48 hours. His admission bloods revealed Serum Bicarbonate of 8, pH 7.19, pCO2 2.7, base excess of -17.8, plasma glucose 5.2 mmol/l and serum alc...

ea0050ep050 | Clinical Biochemistry | SFEBES2017

Starvation ketoacidosis – a rare but significant metabolic condition

Nardeosingh Siddarth , Savage Amy , Banerjee Moulinath

Diabetic ketoacidosis and pregnancy related ketoacidosis are the most common forms of ketoacidosis seen in acute medical units. We describe here two rare cases of starvation ketoacidosis.Case 1: 63 years old gentleman with no history of diabetes, presented with persistent vomiting for 48 hours. His admission bloods revealed Serum Bicarbonate of 8, pH 7.19, pCO2 2.7, base excess of -17.8, plasma glucose 5.2 mmol/l and serum alc...

ea0039oc5.2 | Oral Communications 5 | BSPED2015

Genetic characterisation of children with short stature and GH or IGF1 insensitivity by single gene and whole exome sequencing

Shapiro Lucy , Savage Martin , Metherell Lou , Storr Helen

Background: GH insensitivity (GHI) encompasses growth failure, low serum IGF1 and normal/elevated serum GH. IGF1 insensitivity results in pre- and postnatal growth failure with normal/relatively high IGF1 levels.Objective: To undertake candidate gene (CGS) and whole exome (WES) sequencing to obtain a genetic diagnosis in children with short stature and GHI or IGF1 insensitivity.Methods: As a referral centre for GHI genetics, since ...

ea0061p004 | (1) | OU2019

Evidence of aberrant inflammation in patients with Lipodystrophy

Sajid Sehar , Burke Bernard , Mee Christopher , Savage David , Renshaw Derek

Introduction: Lipodystrophy is a rare medical condition with a varied etiology that is characterised by a complete or partial loss of adipose tissue, which can be generalised, partial or localised. Patients have altered secretion of adipokines, such as, Leptin and Adiponectin. Ectopic lipid accumulation is common and leads to metabolic complications associated with insulin resistance (IR) such as, diabetes mellitus (DM) and hypertriglyceridemia. Levels of circulating inflammat...