Endocrine Abstracts

Gestational diabetes mellitus (GDM) is a common condition affecting 2–10% of pregnant women in the USA and in Europe and is associated with adverse outcomes for both the fetus and the mother. Previous GDM is a major risk factor for type 2 diabetes (T2DM), which occurs in 20–60% of affected women within 5 years of the pregnancy1. In studies comparing women with GDM with those with unaffected pregnancies, relative risks for the development of diabetes after ...

Introduction: Growth differentiation factor 15 (GDF15) has recently been characterized as a cardiovascular risk factor. GDF15 correlates with insulin resistance and obesity in cross-sectional studies and exerts anorexigenic effects in interventional rodent studies. GDF15 has been proposed as a possible therapeutic target in the treatment of obesity, however its meal- and nutrient-dependent regulation in humans has not been investigated previously.Methods...

Introduction: In patients with cured Cushing’s syndrome, comorbidities often persist after remission of glucocorticoid excess. Here we investigate long-term comorbidities in patients with Cushing’s syndrome in remission, and their relationship to metabolic and hormonal markers at the initial diagnosis of the disease.Methods/design: We evaluated 118 patients with cured Cushing’s syndrome (55 Cushing’s disease, 55 adrenal Cushing’s...

Introduction: Cushing’s syndrome is associated with significant chronic and acute complications including acute thromboembolic and cardiovascular events. We aimed to study the prevalence and predictors of acute and perioperative complications in patients with active Cushing’s syndrome.Methods: The prevalence, predictors and outcomes of acute, life-threatening and perioperative complications were evaluated in a cohort of patients with active b...

Acromegaly is amongst other symptoms associated with myopathy, alterations of energy expenditure and insulin action which are mediated by growth hormone (GH) and insulin-like growth factors (IGFs). It is unclear to which extent these abnormalities remain after treatment. Thus, we examined glucose metabolism, intracellular fat deposition and mitochondrial function in patients with prior acromegaly (AM).Six AM (4f/2 m, age: 49±10 years, body mass inde...

Polycystic ovary syndrome (PCOS) affects more than 5% of women in reproductive age and is characterized by a heterogeneous spectrum of oligoanovulation and biochemical or clinical evidence of hyperandrogenism. Insulin resistance and compensatory hyperinsulinaemia play a significant role in pathogenesis of PCOS.Chronic low level inflammation and an increased risk for cardiovascular disease and type2-diabetes are reported in women with PCOS.<p class="a...

Introduction: Pituitary gigantism is a rare disorder caused by GH-secreting lesions.Aim: We studied gigantism for genetic defects.Methods: We performed genome-wide analyses in 46 patients with gigantism and 248 patients with acromegaly.Results: We detected a novel microduplication at chromosome Xq26.3 in two unrelated kindreds and 13 sporadic cases de novo. All patients had disease onset before five ...