Endocrine Abstracts

Thyroid pathology, as a part of Schmidt’s syndrome, could be presented as a chronic autoimmune thyroiditis (95–97%) or as a Grave’s disease (3–5%). Usually refractory hypothyroidism develops after a chronic autoimmune thyroiditis occurs, so the permanent thyroid hormone replacement is necessary during all life. But we are investigating a different course of that disease.A 31-year-old woman had been sick from 2003, when Schmidt’s ...

Introduction: Polyglandular autoimmune syndrome type II (PGA-II) or Schmidt’s syndrome is a very rare autoimmune disorder and difficult to diagnose because the symptoms of this syndrome depends on the gland which gets involved first. Approximately 14–20 people per million population are affected by polyglandular autoimmune syndrome type II. It is characterised by the obligatory occurrence of autoimmune Addison’s disease in combination with thyroid autoimmune dis...

Introduction: Autoimmune polyendocrine syndrome type II (APSII) is more common than APSI. It occurs more frequently in female than in male patients, often has its onset in adulthood, and has familial aggregation. Schmidt’s syndrome is a subset of APSII, usually associated with primary hypothyroidism, primary adrenal insufficiency, and often, type 1 diabetes. This case describes the interesting evolution of autoimmune polyendocrine disease (APED) in a young lady with long ...

A 58-year-old Saudi female presented with fatigue, dizziness and generalised skin hyper-pigmentation. She was diagnosed as Hashimoto’s hypothyroidism. She was diagnosed recently to be diabetic and her blood sugar was controlled with insulin. She reached menopause at the age of 36 years. Lab resultsPatient<td ali...

Introduction: Premature ovarian failure (POF) may be a part of autoimmune polyglandular syndromes that involves multiple endocrine and systemic conditions due to autoimmunity.Material and methods: We aim to present the case of a young women diagnosed with POF and Schmidt syndrome. The patient was followed in different tertiary centers of endocrinology. The informed consent was obtained.Case report: A 31-year old patient with no pri...

Introduction: Schmidt’s syndrome also known as autoimmune polyglandular syndrome type 2 (APS type 2) is a rare endocrine disorder defined by the combined occurrence of Addison disease with autoimmune thyroid disease. The rarity of the condition and the atypical presentation of adrenal insufficiency and hypothyroidism often lead to misdiagnosis with life-threatening consequences for the patient. In this study we report an exhaustive monocentric analysis of 22 patients diag...

Introduction: Bilateral calcification of auricular cartilage is an uncommonly reported condition. The aetiology of this phenomenon is still unclear. Petrified ears have seldom been described in association with endocrinopathies such as adrenal insufficiency, hypothyroidism, diabetes mellitus, and acromegaly.Case report: We present the case of a 42 year-old male patient, diagnosed with Addison’s disease at the age of 14, currently undergoing treatmen...

Introduction: Ketosis-prone diabetes (KPD) is an emerging and uncommon form of diabetes characterized by patients who present with diabetic ketoacidosis without any immunological autoantibody to islet antigens of classic type 1 diabetes. KPD is mostly observed in African-American populations. Multiple, severe forms of β-cell dysfunction appear to underlie the pathophysiology of KPD. The PAX4 gene, causing Maturity-onset diabetes of the young (MODY) subtype 9, alr...

BackgroundIdiopathic Addisons disease is characterised by the presence of adrenal antibodies and a documented variable subclinical period. In previously well controlled Type 1 diabetes, it may present with recurrent hypoglycaemia, or worsening erratic glycaemic control.Case ReportA 24 year old with previously well controlled Type 1 diabetes since age 18 months presented with worsening glycaemic control, 2 sto...

BackgroundIdiopathic Addisons disease is characterised by the presence of adrenal antibodies and a documented variable subclinical period. In previously well controlled Type 1 diabetes, it may present with recurrent hypoglycaemia, or worsening erratic glycaemic control.Case ReportA 24 year old with previously well controlled Type 1 diabetes since age 18 months presented with worsening glycaemic control, 2 sto...