Endocrine Abstracts

The selenoenzyme plasma glutathione peroxidase (GPx3, pGPx) is highly expressed in thyroid, kidney, placenta and bronchio-epithelial tissue. In the thyroid gland, the enzyme is thought to regulate thyroid hormone production by controlling the availability of H2O2, the cosubstrate for thyroperoxidase (TPO) and to protect the thyrocyte against H2O2-induced oxidative damage. To explain the high thyroidal expression levels, we studied GP...

The endocrine active compound 4-methylbenzylidene-camphor (4-MBC) is frequently used as an UV absorber in sunscreens and various skin care products. Though 4-MBC is weakly estrogenic in the reproductive system of fishes and rodents it shows strong anti-osteoporotic effects. Furthermore, different studies show percutanous absorption of 4-MBC after dermal administration resulting in identical biotransformation in humans and rats. Female Sprague-Dawley rats received five concentr...

4-methylbenzylidene-camphor (4MBC) is an endocrine active compound used as an UV absorber in sunscreens and other cosmetics such as anti-aging lotions and day care products. 4MBC shows weak estrogenic effects on the reproductive system but strong anti-osteoporotic effects after chronic application (Seidlova-Wuttke D et al. 2005 Toxicol Appl Pharmacol. 24:in press). Additionally, 4MBC can be resorbed through the skin (Janjua NR et al. 2004 J Invest Dermatol...

UV filters are produced in high amounts for multiple uses. Their main application is in sun lotions for skin protection against accelerated ageing or cancer, but they are also found in many other cosmetics or in plastic materials to prevent their radiation-induced damage. Regardless of these protective properties, UV filters seem to interfere with both the reproductive and the thyroid endocrine axis. We here screened for effects of the UV filter benzophenone 2 (BP2) on thyroid...

Retinoic acid (RA) acts as an anti-proliferative and re-differentiation agent in the therapy of thyroid carcinoma but the molecular mechanisms by which RA mediates these effects are not well understood. We have investigated the effect of RA on the production and post-translational modification of the two ENO1 transcriptional products in the human follicular thyroid carcinoma cell line FTC-133. The single ENO1 transcript encodes a 48 kDa ENO1 with its unique N-terminal enolase ...