Endocrine Abstracts

The German Acrostudy is at present the largest database on acromegalics (n=184) treated with pegvisomant (Somavert®). 91% pts underwent pituitary surgery, 45% received radiation therapy, and previous medical therapy included dopamine agonists (56%), octreotide (90%) and/or lanreotide (10%). Common concomitant diseases at baseline were hypertension (47.0%), diabetes mellitus (31.7%), and gallstone disease (25.6%). Efficacy analysis was performed in 134 pt...

Introduction: Obesity is associated with hypothalamic inflammation (HI) in animal models. While MRI studies in humans also found an increased intensity in the MBH in obese subjects, it remains unclear (1) if HI causes neuronal death and (2) if HI reverses during weight loss.Patients and methods: n=50 obese subjects and n=50 age- and sex-matched controls where examined. MRI scans including spectroscopy were performed. Also, detailed nutr...

Introduction: Changes in the gut microbiome have been associated with the development of obesity. The aim of the present study was to examine i) the effect of a formula based very-low-calorie weight loss diet (VLCD) on the gut microbiome of obese humans and ii) whether if potential changes are sustained during weight maintenance.Patients and methods: The study consisted of 3 months VLCD (~800 kcal/d) followed by 3 months of weight maintenance. 18 obese h...