Searchable abstracts of presentations at key conferences in endocrinology

ea0026p51 | Endocrine disruptors | ECE2011

In vitro testing for goitrogenic potential of glucosinolate extracts

Renko K , Mewis I , Schreiner M , Schomburg L , Kohrle J

Introduction: Glucosinolates (GLS) are secondary plant metabolites found in members of families within the order Brassicales (e.g. broccoli, pak choi, cauliflower, kale, mustard or rapeseed), but they are also present in plants of Moringaceae (moringa) and Caricaceae (papaya). Some GLS-derived breakdown products, i.e. sulforaphane, were extensively studied for their beneficial effects on colon-cancer incidence. This preventive nutritional approach might require the prophylacti...

ea0020p595 | Neuroendocrinology, Pituitary and Behaviour | ECE2009

Growth hormone replacement therapy in adult onset growth hormone deficiency induces favorable long-term effects on quality of life, bone, body composition and lipids: a 55 month prospective study

Jorgensen Anders Palmstrom , Fougner Krisitan J , Schreiner Thomas , Bollerslev Jens

Objective: To investigate long-term effects of GH replacement therapy.Material and methods: Thirty-nine patients (mean age 52.5 years, 14 women) with adult-onset growth hormone deficiency (AOGHD), recruited from a randomized placebo-controlled crossover study of treatment with growth hormone (GH) and placebo for 9months each, were enrolled in an open prospective follow up study. GH replacement was given for additional thirty-three months and was individu...

ea0011p608 | Neuroendocrinology and behaviour | ECE2006

Bone mass and metabolism in active acromegaly – no impact of gonadal status. a study of 73 patients

Fougner SL , Godang K , Ueland T , Schreiner T , Bollerslev J

Background: Growth hormone (GH) is known to have stimulatory effects on bone tissue through a complex interaction of GH, IGF-1 and IGFBPs. The gonadal status is also thought to influence bone metabolism. Bone mass in patients with acromegaly reflects the long-time effects of GH excess on bone. However, data on bone status in acromegaly have been conflicting.Objective: The object of the study was to examine the impact of chronic GH excess on bone mass and...

ea0063oc14.2 | Sex Hormones | ECE2019

The effect of testosterone therapy on serum oestradiol levels in transgender men

Defreyne Justine , Aers Xavier-Philippe , Daphne Fisher Alessandra , Schreiner Thomas , Den Heijer Martin , T'Sjoen Guy

Background: Testosterone therapy in transgender men (TM) is aimed at achieving serum testosterone levels in the male reference range. It remains unknown if serum oestradiol levels in TM should be evaluated and/or adjusted. Although reported serum oestradiol levels in TM are variable in the current literature, these values may be affected through two possible mechanisms: serum oestradiol levels may increase through aromatization of exogenous testosterone, while the effects of e...

ea0049gp121 | Endocrine Tumours | ECE2017

Immunity in adrenocortical carcinoma patients – interplay between anti-cancer immunity and steroid hormones

Sbiera Silviu , Dexneit Thomas , Sbiera Iuliu , Schreiner Jochen , Ronchi Cristina L. , Kroiss Matthias , Fassnacht Martin

Adrenocortical carcinoma (ACC) is one of the most aggressive endocrine malignancies. By applying a ‘multiple omics’ approach, we recently identified two distinct subgroups of ACC patients, a good prognosis “immune” and bad prognosis “steroid” phenotype.We hypothesized that the steroid phenotype is associated with glucocorticoid-induced suppression that can be ‘rescued’ by reactivating the immune system using immune...

ea0049ep1032 | Pituitary - Clinical | ECE2017

Does cyproterone acetate therapy contribute to the observed elevation in serum prolactin levels in trans women?

Defreyne Justine , Nota Nienke , Perreira Cecilia , Thomas Schreiner , Daphne Fisher Alessandra , Guy T'Sjoen

Objective: Hormonal treatment in trans women (MtF transgender persons) in Europe usually consists of estrogens and anti-androgens, e.g. cyproterone acetate (CPA). After initiation of cross-sex hormone therapy, an elevation in serum prolactin levels is frequently observed in trans women, which was previously attributed to estrogen agents. This analysis evaluates whether CPA contributes to the elevation of prolactin in trans women receiving cross-sex hormones.<p class="abste...

ea0041ep397 | Developmental endocrinology | ECE2016

Cross-sex hormone therapy affects body fat distribution in transgender persons

Klaver Maartje , Dekker Marieke , Schreiner Thomas , Fisher Alessandra , T'sjoen Guy , den Heijer Martin

Introduction: Fat distribution is an important secondary sex characteristic, which is generally peripherally or pear-shaped (gynoid) in females and centrally or apple-shaped (android) in males. Total body fat increases in male-to-females (MtFs) and decreases in female-to-males (FtMs) during cross-sex hormone therapy (CSHT), approaching body fat amounts of the desired sex. However, changes in android or gynoid fat distribution might be a better measure for masculinization and f...

ea0070oc1.4 | Adrenal and Cardiovascular Endocrinology | ECE2020

Immune infiltrate and PD-1 / PD-L1 expression in adrenocortical carcinoma: who can predict patients´ outcome?

Landwehr Laura-Sophie , Sbiera Iuliu , Schreiner Jochen , Weigand Isabel , Kroiss Matthias , Fassnacht Martin , Sbiera Silviu

Context: Adrenocortical carcinoma (ACC) are endocrine malignant neoplasms associated with severe aggressiveness. Tumour-related glucocorticoid excess occurs in 60% of patients and is associated with poor prognosis. First clinical trials using immune checkpoint inhibitors are quite unsatisfactory and treatment advancements are urgently needed.Recently, we characterized tumour-infiltrating lymphocytes (TILs) in ACC and identified the detrimental dependency...

ea0070aep83 | Adrenal and Cardiovascular Endocrinology | ECE2020

JIL-O: Establishment of a new steroidogenic human adrenocortical carcinoma cell line

Landwehr Laura-Sophie , Jochen Schreiner , Herterich Sabine , Appenzeller Silke , Fassnacht Martin , Kroiss Matthias , Weigand Isabel

Adrenocortical carcinoma (ACC) is a rare malignancy with heterogeneous but dismal prognosis and despite numerous efforts to improve patient care, effective treatment options are still lacking. ACC in vitro research faces for decades one major obstacle - the unavailability of different ACC cell line models. Here, we present a newly established human ACC cell line that was directly transferred to and now proliferates in cell culture. JIL-O cell line was derived from a p...

ea0032p189 | Cardiovascular Endocrinology &amp; Lipid Metabolism | ECE2013

Metabolic profile of transsexual persons on cross-sex hormonal therapy in a multi-center prospective intervention study

Van Caenegem Eva , Wierckx Katrien , Taes Youri , Kaufman Jean-Marc , Schreiner Thomas , T'Sjoen Guy

Introduction: Gender differences in insulin resistance, body composition and lipid profile are well known and related to sex steroid hormones. In this study, we examine the metabolic profile of transsexual persons undergoing drastic sex steroid changes, during the first year of hormonal therapy.Design: This research is part of a prospective intervention study conducted in several European gender teams (Ghent, Oslo, Amsterdam, and Florence).<p class="...