Searchable abstracts of presentations at key conferences in endocrinology

ea0089b15 | Basic Science | NANETS2022

Targeting the TCA Cycle with Histone Deacetylase and Nicotinamide Phosphoribosyltransferase Inhibitors Uncovers a Critical Role for YAP1 in Neuroendocrine Cells

Scotto PhD Luigi , Safari PhD Maryam , Hou Ping , Fojo, MD PhD Tito , Bates MD Susan

Background: More than 12,000 people in the United States are diagnosed with a NET each year and approximately 175,000 people are living with this diagnosis. Little progress has been made in the therapy of NETs over the last two decades, and identification of new vulnerabilities remains a priority.Methods: We used two libraries of compounds selected for potential repurposing and identified agents with the highest cytotoxic activity in neuroendocrine model...

ea0049oc11.2 | Obesity | ECE2017

Three year prospective study in morbidly obese patients between longitudinal gastrectomy and gastric bypass based on a composite outcome combining weight loss efficacy and surgery related complications (PHRC SLEEVE K060213 / IDRCB2007-A00373-50)

Catheline Jean Marc , Fysekidis Marinos , Bendacha Yasmina , Bdeoui Najib , Raghavan Vidhya , Gerard Sophie , Portal Jean Jacques , Dbouk Rami , Fabre Jean Michel , Fourtanier Gilles , Gugenheim Jean , Huten Noel , Sodji Maxime , Msika Simon , Scotte Michel , Vicaut Eric , Cohen Regis

Since its first description in 2000, Longitudinal Gastrectomy (LG) has become the first surgical procedure in the treatment of morbid obesity in the world, exceeding in numbers Gastric Bypass (GB). GB is considered to have better results regarding long-term weight loss and improvement in co-morbidities. We aimed to demonstrate that LG is non inferior to GB for a composite end point that included more than 50% excess weight loss from the baseline and surgery related complicatio...