Searchable abstracts of presentations at key conferences in endocrinology

ea0011p297 | Diabetes, metabolism and cardiovascular | ECE2006

Decreased cardiac and arterial noradrenaline and dopamine concentrations occur concomitantly with the development of type II diabetes in rats treated neonatally with monosodium glutamate (MSG): a possible basis for autonomic neuropathy?

Morrison JFB , Shaffiullah M , Dhanasekaran S , Sheen R , Mensah-Brown EK

Neonatal rats were treated with MSG (4G/Kg daily for 7 days). Glucose tolerance tests (GTT) were performed at 32, 65 and 70 weeks. After one year there was evidence of Type II diabetes, and the blood glucose levels were significantly greater than the controls for several points in the GTT; islet beta-cells were unchanged, cataracts were often present and there was central obesity.The amines in the heart, proximal tail artery, kidneys and adrenals were ex...