Endocrine Abstracts

Pituitary growth hormone (GH) like a number of other protein hormones, shows an episodic pattern of evolution, in which periods of prolonged near-stasis are interrupted by short bursts of rapid change. During mammalian evolution two episodes of rapid change of GH have been identified, one in the Artiodactyla and one in the Primates. The latter underlies the well known species specificity of human GH. Cloning and characterisation of GH genes for a number of mammalian species ha...

The relation between testosterone (T) production and action is complex, involving protein binding in the circulation affecting clearance and tissue availability, T production from precursors in peripheral tissues, deactivating and activating (to dihydrotestosterone and estradiol) metabolism within target tissues, besides factors affecting androgen responsiveness (receptor concentrations, cofactors, genetics,…). Yet, in absence of a useful independent marker of androgen a...

The relation between testosterone (T) production and action is complex, involving protein binding in the circulation affecting clearance and tissue availability, T production from precursors in peripheral tissues, deactivating and activating (to dihydrotestosterone and estradiol) metabolism within target tissues, besides factors affecting androgen responsiveness (receptor concentrations, cofactors, genetics,…). Yet, in absence of a useful independent marker of androgen a...

Fenhexamid (Fen) and cyprodinil (Cyp) are antifungal agents used in agricultural applications. In this study, to examine the effects of two-pesticides on cancer cell viability and metastasis via estrogen receptor pathway, the ER positive-MCF-7 and ER negative-MDA-MB-231 breast cancer cells were used. MCF-7 and MDA-MB-231 were cultured with 0.1% DMSO (control), 17β-estradiol (E2; 1×10−9 M), Fen (10−5–10−7</s...