Endocrine Abstracts

Case history: A 65 year-old Caucasian gentleman was admitted with out-of-hospital VF arrest at work place. ROSC was achieved after shock by paramedics but developed multiple in-hospital arrests requiring (>100 shocks in 24 h) with incessant polymorphic ventricular tachycardia which was resistant to anti-arrhythmic therapy including drugs and pacing. Investigations revealed hypercalcemia and newly diagnosed high PTH with no change in mild LV dysfunction from previous myocardial...

40year old bodybuilder was re-referred to clinic with low mood, reduced libido, poor morning erections and fatigue. His past medical history included hypogonadal hypogonadism secondary to anabolic androgen abuse, mental health disease and personality disorders. He had undergone breast reconstruction surgery for bilateral gynaecomastia secondary to anabolic steroid use despite taking precautionary tamoxifen injections as per peer groups’ advice. Previously, he was lost for...

Thyroid dysfunction is associated with well-recognised maternal and fetal complications. There is an increase in thyroxine requirement during pregnancy by 25–50% hence close monitoring of thyroid function and dose augmentation is vital in attaining euthyroid status. In our combined antenatal-endocrine clinic we aim to test thyroid function tests (TFTs) at booking, in the second and third trimesters. In order to reduce the need for patients to re-attend the clinic purely f...

Introduction: Diabetes striatopathy (DS) is an extremely rare hyperglycaemic complication of diabetes with a prevalence reported as 1 in 100,0001. Though DS is commonly associated with a non-ketotic hyperglycaemic hyperosmolar state (HHS), it is occasionally reported in diabetic ketoacidosis (DKA). DS is known as non-ketotic hemichorea-hemiballismus due to its presentation with hyperkinetic movements but rarely presents as stroke-mimic2. Here we present a...

Introduction: Endocrine late effects can manifest in hemopoietic stem cell transplantation survivors who were exposed to myelosuppressive conditioning treatment. These include dysfunction of the hypothalamic/pituitary, thyroid, and gonads leading to premature ovarian insufficiency and primary amenorrhoea. In addition, metabolic dysregulation and increased risk of diabetes have been observed in these patients. The investigation for primary amenorrhoea in this condition can rare...

Background: Gestational diabetes mellitus (GDM) occurs in every 23 UK pregnancies. GDM identifies the mother as high-risk for development of type 2 diabetes. The National Institute for Health and Care Excellence (NICE) published updated guidance in February 2015 recommending routine follow-up of women with GDM.Aims: This cohort study compared follow-up rates of women with GDM before and after the updated guidance. We also investigated for an association ...

CD38 is an enzyme which catalyses the production of the second messengers cyclic ADP ribose and nicotinic acid adenine dinucleotide phosphate which mobilize calcium from ryanodine-sensitive intracellular calcium stores. Intracellular calcium is well known to be important for mobilisation of secretory granules to the plasma membrane in preparation for exocytosis and CD38 signalling has recently been demonstrated to increase posterior pituitary oxytocin release (Jin et al.</i...

Cyclic Cushing’s syndrome (CCS) is a rare condition that involves recurring episodes of hypercortisolaemia, alternating with normocortisolemia at intervals ranging from a few days to several years. To diagnose CCS, it is necessary to demonstrate three cortisol peaks and two troughs. CCS is mostly seen in females and can be Adrenocorticotropic hormone (ACTH)-dependent or independent2. The common causes of CCS are Cushing’s Disease (55% ), ectopic ACTH syndrome (26%), ...

Background: Small for gestational age (SGA) and short stature at birth can be defined as birth weight (BW) and birth length (BL) ≤−2 S.D.. Affected neonates can be classified as: i) SGA, ii) Short, iii) SGA + Short. Catch-up growth occurs by age 6 months in 90–95% of Short and SGA + Short infants. A minority remain short after age 2–4 years when the lack of data on BL and parental height (PH) renders assessment difficult.<p class="abste...

Introduction: Following a National training programme for Endocrinologists to provide RAI treatment for benign thyroid disease, the ESHT NHS Trust started Radioactive iodine (RAI) treatment for benign thyroid disease a couple of years ago. Previously ESHT trust patients were referred to neighbouring trusts for RAI treatment.Data/Results: The data was collected over a 12-18 month period. A total of 34 patients received RAI treatment during this period; 28...