Endocrine Abstracts

Type 2 Diabetes Mellitus (T2DM) is associated with decreased bone quality and a higher prevalence of fractures. Sclerostin is an inhibitor of bone formation produced by osteocytes and its expression is elevated in serum of diabetic patients. We examined the effect of T2DM on bone architecture and sclerostin levels in a rat model of T2DM and the influence of hyperglycaemia on sclerostin production by bone cells in vitro. Bone architecture was measured by microCT in 14 ...

A 30-year-old female reported a 2-year history of excessive sweating / flushing affecting the right hand side of the face and scalp along with the right arm. These symptoms were generally related to exercise and demonstrated a sharp midline demarcation, being present only on the right hand side.Past medical history included hypothyroidism secondary to Hashimoto’s Thyroiditis. She was euthyroid on levothyroxine. She also reported unequal pupils since...

A 65-year-old female, with a 4 month history of left upper quadrant discomfort, was identified as having a multi-loculated para-renal ‘cyst’ on ultrasound scanning. CT identified a 13×11×10 cm heterogeneous mass arising from the left adrenal. An enlarged ill-defined left retro-crural ‘lymph node’ was also noted. There was no history of weight loss. Past medical history was unremarkable. She was no medication. Examination was unremarkable apart fro...

Background: More than 12,000 people are diagnosed with neuroendocrine malignancies each year in the US. There are limited data on YO-NETs/YO-NECs. In the present study, we seek to evaluate clinical characteristics/trends of patients with GI-YO-NETs and GI-YO-NECs.Methods: Using the National Cancer DataBase, NCDB, we identified 124,081 GI-NETs and 52,063 GI-NEC cases 18 or older, diagnosed between 2004 and 2019. Histology codes to identify NETs and NECs w...