Endocrine Abstracts

Objective: To analyze the role of miRNAs previously found to be differentially expressed in patients with ACTH-dependent Cushing syndrome (CS).Materials and methods: We analyzed putative targets of three microRNAs, which were previously found to be differentially expressed in ACTH-dependent CS patients: miR-16-5p, miR-145-5p, miR-7g-5p. We used TargetScan (TS) and DIANA tools (DT) predictions.Results: We found different plasma expr...

Molecular basis of the bone disorders in patients with acromegaly are largely unknown.Objective: To investigate microRNAs (miRNA) expression profiles that regulate bone metabolism in plasma samples from patients with acromegaly.Materials and methods: Fasting plasma samples were taken from consecutive subjects with biochemically confirmed active acromegaly and healthy volunteers matched by age, sex and BMI. IGF1 was measured by an e...

Background: Plasma microRNAs (miRs) (miR-4446-3p, miR-215-5p, miR-342-5p) were downregulated in patients with active acromegaly (AM) compared with healthy control subjects as assessed by next-generation sequencing.Aim: The aim of this study wasto validate the previously observed finding in the newly enrolled patients with AM using qRT-PCR.Materials and methods: Morning plasma samples were collected from fasting patients with AM and...

According to previous research microRNA (miR) are expressed differently in corticotropinoma and ACTH-secreting neuroendocrine tumors. MiR are released into circulation by several mechanisms and considered to be promising biomarkers.Objective: To evaluate whether preselected miR are differently expressed in plasma samples of patients with ACTH-dependent Cushing’s syndrome (CS).Materials and methods: The blood samples were colle...

Introduction: Recent studies have shown that microRNA could serve as biomarkers in various types of cancer and other diseases. Aim: To reveal microRNA that differ in patients with Cushing’s diseases (CD) and Ectopic ACTH-syndrome (EAS) to form a specific panel for differential diagnosis of ACTH-dependent Cushing’s syndrome (CS).Materials and Methods: Plasma samples from both sinuses and cubital vein were drained during in...