Endocrine Abstracts

Mortality risk is increased in acromegalics, due to cerebrovascular and cardiovascular events. These events are namely related to atherosclerotic vascular alterations, both at coronary and peripheral level. Systemic comorbidities increase the risk of atherosclerosis, but the role of GH and IGF-1 excess is still debated. To evaluate the relationship between GH/IGF-1 excess, systemic atherogenic complications and vascular alterations we investigated stiffness index (β), pul...

Sleep related breathing disorders (SRBD), due to bone mass and soft tissue swelling of the upper airways, are frequently reported by acromegalic patients, but sleep disorders other than SRBD were rarely studied in acromegaly. We evaluated 38 acromegalics (14 M, 24 F, age 52.8±2.3 yrs) by a structured interview for insomnia, excessive daytime sleepiness (EDS), SRBD, sleep related movement disorders (SRMD), circadian sleep disorders and parasomnias. Epworth sleepness scale ...

Osteoporosis and the associated low- energy fractures is a major public health problem. Phytoestrogens, especially from soy foods with isoflavones, carry the potential of being a nutritional candidate for prevention of osteoporosis. Several studies have been performed to determine the role of soy intake in preventing bone loss in postmenopausal women. Studies with fracture endpoint are not yet available, but several other lines of evidence have been investigated: epidemiologic...