Endocrine Abstracts

There are three distinct types of gastric Neuroendocrine tumours using the ENETS classification system. Type 1 gastric NETs are most common, accounting for 55–70% of all gastric NETs. Epidemiology studies have suggested an increasing incidence of gastric NETs. Generally type 1 gastric NETs are multifocal in nature and arise in a background of chronic atrophic gastritis. Type 1 Gastric NETs arise from histamine secreting ECL cells, hypergastrinaemia due to excess gastrin r...

Accumulating evidence suggests that the immunological landscape plays a key role in the progression of neuroendocrine liver metastases (LM-NENs), which is often characterised by immune cell infiltration. Anti-tumour functions of infiltrating lymphocytes are often silenced through hyper-expression of inhibitory checkpoint receptors (CRs) such as PD-1, but favourable outcomes with anti-PD-1 therapy have been low. Recently, functional soluble (cell-free) CRs beyond PD-1 have been...

Background: Colorectal cancer is the third most common cancer in the UK this had led to development of the bowel cancer screening programmes (BCSPs). It is known that ileo-colonic NETs are increasing in incidence in part thought to be related to increased endoscopy. There are few epidemiological data on rectal or ileal NETs diagnosed in BCSPs. This study aims to identify the number of NETs diagnosed through the UK BCSP.Methods: UK bowel cancer colonoscop...

Introduction: Carcinoid heart disease (CHD) develops in patients with small bowel NETs with carcinoid syndrome. Currently NT-proBNP (NTP) is suggested as the best current biomarker to screen for CHD and monitor heart failure. A number of other markers have been investigated for heart failure, however, none of these have been explored in NET patients with CHD or carcinoid syndrome. Galectin-3 (GAL3) promotes fibroblast proliferation and correlates with worse outcomes in heart f...

Introduction: Pulmonary NENs account for around 2% of all pulmonary malignancy. They are classified histologically into 4 types typical and atypical carcinoids which are generally well differentiated and large cell neuroendocrine carcinoma (LCNEC) and small cell lung carcinoma (SCLC) which are poorly differentiated. Within the literature there are several reports regarding overall survival on small mainly surgical cohorts, but data for the UK population are lacking. Only a few...

Introduction: Patients with neuroendocrine neoplasia (NEN) may experience psychological distress related to secretory effects of the tumour. 5-hydroxyindoleacetic acid (5-HIAA) is a metabolite of serotonin, the most important secretory product in carcinoid syndrome. This study aims to determine if urine 5-HIAA levels correlate with health-related quality of life (HRQoL) in patients with NEN.Methods: A retrospective single-centre cohort study was conducte...

Introduction: Previously published UK Cancer Registry data showed incidence of Neuroendocrine Neoplasms rising between 2001 and 2015. This was higher than had been thought (Genus et al.). We report more recent data with more accurate coding (ICD-O-3).Aim: To analyse National Cancer Registration and Analysis Service (NCRAS) data on Neuroendocrine Neoplasias (NENs) in England including years 2015–2017.Methods: Public He...

Background: Gastric and duodenal neuroendocrine tumours are increasing in incidence. ENETS guidelines suggest endoscopic resection of type 1 gastric NENs over 10 mm and consider endoscopic resection for duodenal NENs. However, the endoscopic techniques are not clearly mandated. There, is evidence to suggest endoscopic mucosal dissection has higher incidence of R0 resections compared with polypectomy or EMR alone. We have reviewed our data of endoscopic resection of gastro-duod...

Introduction: The aetiology of NENs vary; some are sporadic, others familial. An association between index NENs of the mid gut (ileum and colon) with subsequent colorectal primaries has been reported.Aim: We determined to evaluate the relationship between the diagnosis of an index primary malignancy and subsequent diagnosis of NEN.Methods: A population-based retrospective cohort study was under taken for persons with NEN diagnosis ...

Introduction: Up to half of patients with carcinoid syndrome develop carcinoid heart disease; this is thought to be mediated by serotonin from disordered tryptophan metabolism. Valve degeneration can lead to right heart failure which drives morbidity and mortality in this patient population. Surgical replacement of affected valves is an effective therapy. Peptide receptor radiotargeted therapy (PRRT) has demonstrated better progression-free survival compared to high dose sando...