Endocrine Abstracts

Congenital adrenal hyperplasia (CAH) is an autosomal recessive condition which leads to glucocorticoid deficiency. During childhood, aims of treatment are to prevent adrenal crisis and to achieve optimal adult height and normal puberty. In adults, aims of treatment are to prevent adrenal crisis, ensure normal fertility and avoid long-term consequences of glucocorticoid use. Current regimens with glucocorticoids cannot optimally replicate the normal physiological cortisol level...

Introduction: Lymphocytic hypophysitis (LH) is a rare condition that has been increasingly recognised. We studied the natural history and current management of patients with lymphocytic hypophysitis.Methods: We performed a multi-centre retrospective review of all patients that either had histologically proven disease or a strong clinical suspicion for its presence, diagnosed from 2000 onwards. Cases of secondary hypophysitis or granulomatous or xanthomat...

A 51-year-old obese lady was admitted with multiple cerebral, pulmonary and intra-abdominal abscesses. She was referred to the endocrine team because of newly-diagnosed type 2 diabetes mellitus. The combination of apparent immunosuppression, obesity, diabetes mellitus, hypertension, hypokalaemia, osteoporotic fractures and bilateral shoulder avascular necrosis (BSAN) led to a clinical diagnosis of Cushing’s syndrome (CS); this was biochemically confirmed as follows: non-s...

Case: A 41 year-old-Indian woman with type 2 diabetes treated with liraglutide was admitted to the Emergency Department with abdominal pain, nausea, vomiting and bloated abdomen. She was found to have raised amylase at 706 U/l. Abdominal ultrasound and CT scan did not reveal any abnormalities in the pancreas or billary tract and the patient was discharged.She had diabetes for 9 years duration treated with metformin, pioglitazone and liraglutide. Over 2 y...

Introduction: Follicle stimulating hormone receptors (FSHR) are physiologically expressed in gonads. FSHR are also expressed in gonadal cancers, but nothing is known on FSHR appearance in non-gonadal endocrine tumors. The present paper reports on the immunohistochemical detection of FSHR in pituitary, thyroid, adrenal and neuroendocrine tumors (NET).Materials and methods: The study included samples of 80 endocrine tumors (28 pituitary adenomas, 7 thyroid...

Endostatin, a cleaved fragment of collagen XVIII, is a potent endogenous angiogenesis inhibitor. Elevated serum endostatin levels have been recently reported in patients with various types of neoplasms. The purpose of our study was to evaluate serum concentrations of endostatin in patients harbouring various types of pituitary adenomas and to examine the relationship of serum endostatin levels to circulating vascular endothelial growth factor (VEGF) levels. Preoperative serum ...

Introduction: Substrate accumulation, energy deficiency or complex molecule defects characterize inherited metabolic disorders (IMDs), accounting for their multi-system manifestations. One important aspect of this is endocrinopathy, which is relatively common but underestimated in IMDs, presenting in childhood following diagnosis or sometimes a presenting symptom in adults where there is multi-system or multi-gland involvement. Endocrinopathies may be secondar...

The aim of the reported study was to assess gene expression levels of the OPG/RANK/RANKL system in peripheral blood mononuclear cells (PBMC) after tibolone and hormonal replacement therapy (HRT) administered to patients with oestrogen deficiency symptoms and osteopenia or postmenopausal osteoporosis.Material and methods: 74 women after menopause, aged 45–71 years, were enrolled into the study and randomly assigned to different medical therapies: HRT...

The aim of this study was to evaluate quantitative changes in OPG and RANKL proteins after tibolone and hormonal replacement therapy (HRT) administered to patients with oestrogen deficiency symptoms and osteopenia or postmenopausal osteoporosis.Material and methods: A total of 74 women after menopause, aged 45–71 years, patients of the Outpatient Clinic of Osteoporosis of the Military Teaching Hospital in Lodz, were enrolled into the study. The pati...

Background: It is estimated that gestational diabetes (GDM) accounts for 87.5% of all diabetes cases in pregnancy and is associated with worse pregnancy outcomes. Macrosomia is one of the main complications of GDM and antenatal management strategies are directed at ensuring normal foetal growth. Ultrasonography is a useful tool for estimating foetal size, but there is little data in the literature correlating foetal abdominal circumference (AC) and birth weight in GDM. Further...