Endocrine Abstracts

Background: Neutropenia due to anti-thyroid drug (ATD) therapy in Graves’ disease is rare but is well recognised. However, the effect of hyperthyroidism, prior to and after ATD therapy, on absolute neutrophil counts in patients with Graves’ disease is unclear.Methods: We noted neutrophil levels in consecutive patients with newly diagnosed Graves’ thyrotoxicosis in 2010–2013. We further noted neutrophil levels once patients had been tr...

Constitutive neurogenesis in the adult mammalian brain (sub-ventricular zone, SVZ and dentate gyrus) implies the capacity for self-repair following brain injury. However, brain injury is usually permanently debilitating as neuronal self-repair responses are not sustained and resident neural stem cells (NSC) do not repopulate damaged tissue. Identification of NSC differentiating factors transiently activated post-injury will be key to enhancing NSC mobilisation and differentiat...

Adult progenitor cells exist in most adult tissues, their differentiation being primed by insult, repopulating damaged or dysfunctional tissue. Utilisation of resident progenitor cells has the potential to cure many diseases, including neurodegenerative disorders or diabetes which presently can only be managed. This potential is limited in the brain by constraints on endogenous progenitor cell mobilisation and by difficulties in progenitor cell harvesting for ex vivo ex...