Endocrine Abstracts

Background: Adiponectin and resistin belong to the group of adipocytokines, that are thought to be involved in regulation of insulin sensitivity, and that also exert the opposite effects on inflammatory processes related to atherosclerosis and cardiovascular risk. Glucocorticoids have anti-inflammatory properties, but also increase insulin resistance. There are, however, conflicting data on the effects of glucocorticoids on serum concentrations of adiponectin and resistin....

Background and aims: Mechanism underlying the IR (Insulin-resistance) remains yet to be identified. Resistin has been shown to antagonize insulin action, and thus might be implicated in the pathogenesis of IR. In contrast, adiponectin has been shown to increase insulin sensitivity and improve glucose tolerance. We aimed to test the hypothesis that resistin levels might correlate positively with the indices of insulin resistance, while the opposite might be true for adiponectin...

It is recognized that a substantial proportion of patients found to have raised prolactin (PRL) level on a single testing is subsequently found to have normal PRL levels. Though this is often attributed to stress or medication factor, it should be noted, that PRL secretion displays diurnal variation with a nocturnal peak in the late-night/early morning hours. In our study we tested the hypothesis, that in some patients raised PRL levels in the morning may reflect individual di...

Introduction: Obesity does constitute one of the most common modifiable risk factors for cancer. The process of cancerogenesis is associated with the enhanced oxidative stress. Lipid peroxidation (LPO), resulting from oxidative damage to membrane lipids, as well as oxidative damage to DNA, are the most frequently examined processes to evaluate oxidative damage to macromolecules.Aim: The aim of the study was to evaluate the level of oxidative damage to me...

Bivalent iron (Fe2+), which initiates the Fenton reaction (Fe2++H2O2+H+→Fe3++•OH+H2O), is frequently used to experimentally induce oxidative damage to macromolecules. Growth hormone (GH) and the main mediator of its action – insulin-like growth factor-I (IGF-I) – are involved in oxidative processes, lipid peroxidation (LPO) included.The aim of the...

Iron participates in the Fenton reaction (Fe2++H2O2+H+→Fe3++•OH+H2O), the most basic reaction of oxidative stress. This transition metal is required to keep oxidative balance, although iron overload is associated with enhanced oxidative damage and cancer initiation. Growth hormone (GH) and insulin-like growth factor-I (IGF-I) are also involved in oxidative processes, lipid peroxidation incl...