Endocrine Abstracts

DTC carries a good prognosis when adequately treated by means of total thyroidectomy, iodine-131 (I-131) treatment and TSH-suppressive therapy, and carefully followed up (i.e. serum thyroglobulin, I-131 total). In some cases, however, false-positive scans can occur. A 42-yr-old woman with recurrent chest infections and bronchiectasis was submitted to total thyroidectomy because of a13 mm nodule in the right lobe that showed a papillary thyroid carcinoma at FNAB histological ex...

The prevalence of thyroid nodules is increased in the elderly. The aim of this study was to evaluate the accuracy of US and US-FNAB in the diagnosis of thyroid cancer in a population of elderly subjects, all of whose thyroid nodules were subjected to US-FNAB, with no prior selection based on dimensions or echo-pattern. Over a three-year period, 276 consecutive patients (64 males and 212 [76.8%] females), aged 65 to 87 (mean 70±4.4), underwent US evaluation and US-FNAB of ...

Testosterone (T) can induce SSC in young HH men. So far the T ester formulations have been used for inducing puberty in these patients. Moreover, it seems that the polymorphism CAG length of androgen receptor (AR-CAG) might co-regulate the effectiveness of testosterone therapy (Tth).This study aims to evaluate the effectiveness of Nebid (1000 mg) for SSC induction in HH men and, secondly, whether these changes might be modulated by the AR-CAG.<p clas...

The aim of this study was to define the occurrence of hypothyroidism and its impact on CHF progression. Four hundred and twenty-two consecutive outpatients (326 males, aged 65±12 years) with CHF in stable condition and conventional therapy were evaluated. Thyroid status was checked at least every 4 months. The progression of heart failure was defined as death, urgent heart transplantation, or hospitalisation due to worsening HF.<img src="/ea/0026/ima...

Amiodarone, an iodine-containing antiarrhythmic drug frequently used in chronic heart failure (CHF) patients, is often the cause of primary hypothyroidism. It has not been well investigated, however, whether its use could lead to a poor prognosis in these patients by inducing and/or worsening thyroid function. The aim of this study was to evaluate the prognostic significance of hypothyroidism detection in CHF outpatients treated with amiodarone. Out of 355 patients affected by...

The aim of this study was to evaluate the prognostic role of subclinical hypothyroidism in patients with chronic heart failure (CHF). We evaluated 338 consecutive outpatients (260 male; age 64±13) with stable CHF (NYHA class 2.3±0.6) receiving conventional therapy (ACE inhibitors and/or ARBs 93%, Beta-blockers 88%, Digitalis 26%, Diuretics 85%, Spironolactone 54%, Amiodarone 32%). The patients underwent a physical examination, electrocardiography and echocardiography...

Aim: Aim of the study was the evaluation of the effects of chemotherapy on insulin secretion and insulin sensitivity in patients affected by acute leukaemia.Materials and methods: Thirty-two non-diabetic patients (17 male, 15 female; age 51.1±17.4, range 16–76 years; BMI=25.1±3.7, range 18.4–32.8 kg/m2; 6=18% with a family history of diabetes mellitus) affected by acute leukaemia, 4 LLA (12.5%) and 28 LMA (87.5%), have been...

Aim of this study was the evaluation of the accuracy of ultrasound and US-FNAB in the diagnosis of thyroid cancer in a population of subjects submitted to US-FNAB of all thyroid nodules, with no prior selection. 1803 patients (1447 females e 356 males, age range 11 – 87 years, mean 49.6±13.7, with a total of 3378 nodules) were submitted by the same physician (first author) to ultrasound evaluation and US-FNAB of all thyroid nodules. Results. The nodules were 3 to 90 ...

Parathyroid lesions are often occasionally discovered during thyroid ultrasound evaluation (incidentalomas); in other cases there is a previous diagnosis of hyperparathyroidism. In many cases it is difficult or even impossible to distinguish these lesions from those of thyroid origin, because they often share common ultrasound features. Scintiscan and cytology are also frequently inadequate. The aim of this study is to evaluate the contribute of PTH determination in the aspira...

Prepuberal-onset HH (PRHH) and postpuberal-onset HH (PSHH) men required GnTh by means of administration of both the β human chorionic gonodadotropin (ηHCG) and the FSH to induce a complete spermatogenesis. However, the response to GnTh is always unpredictable concerning either the effectiveness or the duration of the therapy. Consequently, different studies have been carried out to identify clinical and biochemical markers that can be useful to predict the effectiven...