Endocrine Abstracts

Objective: Interleukin-6 (IL-6) is an immunoregulative proinflammatory cytokine with pleiotropic functions. It was reported that plasma level of IL-6 in type 1 diabetes mellitus (T1DM) patients was higher than in healthy individuals. IL-6 is supposed to take part in pancreatic beta-cells destruction. So, we considered IL-6 gene to be a candidate one for T1DM. The aim of present study was to investigate the role of IL-6 gene promoter polymorphism in T1DM developme...

Our aim was to evaluate the impact of some clinical (obesity, metabolic syndrome), biochemical (HOMA-IR), histological (fibrosis, necroinflammation, steatosis) and viral factors (HCV viraemia) on both EVR and SVR in patients with genotype 1 chronic hepatitis C (CHC) treated with peginterferon plus ribavirin.Patients and methods: We evaluated retrospectively 188 naïve patients with CHC treated with peginterferon plus ribavirin at standard weight-base...

Introduction: Cystic lesions of the adrenals are rare and they may develop asymptomatically for a long period of time. Females seem to be more affected and lesion is typically unilateral.Aim: We report a case of young female case incidentally found with a large adrenal pure cystic mass.Case data: A 24-year non-smoking female patient with regular menses since the age of 14 complained of mild abdominal pain for a few days without cor...

Background: Kisspeptin is a novel hypothalamic hormone with powerful stimulatory effects on the hypothalamo-pituitary–gonadal (HPG) axis. Inactivating mutations in the kisspeptin receptor lead to pubertal failure. We have previously demonstrated that injection of kisspeptin-54 stimulates LH release in healthy men and women. Recent studies in animals suggest that endogenous kisspeptin may be involved in stimulating the GnRH pulse generator. Determining whether exogenous ad...

The physiological post-prandial release of the gut hormones PYY and GLP-1 is implicated in triggering CNS mechanisms underlying satiety. However, the combined effects of PYY and GLP-1 on brain circuits underlying satiety in humans remain unknown.Objective: To determine changes in CNS neuronal activity following single and combined infusions of PYY and GLP-1, using blood oxygen level dependent functional magnetic resonance imaging (BOLD fMRI) in human vol...

Polycystic ovary syndrome (PCOS) is associated with insulin resistance. Abnormally low glucose transporter 4 (GLUT4) expression has been shown in adipocytes from subjects with PCOS1 and skeletal muscle from type 2 diabetics2. Although GLUT4 expression is mostly restricted to classic insulin target tissues such as skeletal muscle, cardiac muscle and adipose, we have found it in granulosa cells (GCs) of mice3. Glucose uptake and metabolism by GCs...