Searchable abstracts of presentations at key conferences in endocrinology

ea0050d1.1 | This house believes that the UK population trend in obesity cannot be reversed without food taxation | SFEBES2017

Debate: this house believes that the UK population trend in obesity cannot be reversed without food taxation

Taylor Roy

The epidemic nature of obesity/overweight throughout the developed and less-developed world suggests that major new influences are at play. Correct identification of these influences must precede discussion of what action can rationally be planned. The widespread failure to recognise that this problem concerns the whole population and not merely those with a BMI over the arbitrary normal level is a critical factor in appreciating the nature of the problem. The lack of efficacy...

ea0050d1.1 | This house believes that the UK population trend in obesity cannot be reversed without food taxation | SFEBES2017

Debate: this house believes that the UK population trend in obesity cannot be reversed without food taxation

Taylor Roy

The epidemic nature of obesity/overweight throughout the developed and less-developed world suggests that major new influences are at play. Correct identification of these influences must precede discussion of what action can rationally be planned. The widespread failure to recognise that this problem concerns the whole population and not merely those with a BMI over the arbitrary normal level is a critical factor in appreciating the nature of the problem. The lack of efficacy...

ea0059s8.2 | Thyroid in pregnancy | SFEBES2018

CATS Obstetric and development – implications for thyroid screening in pregnancy

Taylor Peter

Low thyroid function in pregnancy is associated with adverse obstetric outcomes but it is unclear whether screening and initiation of levothyroxine during pregnancy is beneficial. The Controlled Antenatal Thyroid Study (CATS) was a randomised controlled trial which screened women for low thyroid function (subclinical hypothyroidism and isolated hypothyroxinemia) between 11 and 16 weeks gestation. CATS provides data on obstetric outcomes and offspring neurological development. ...

ea0010s18 | Hormone measurements: past, present and future | SFE2005

Steroid profiling

Taylor N

Techniques of analysis of urinary steroid metabolites evolved rapidly in the 1960 s from paper via thin layer and gas-liquid chromatography (GC) to GC-mass spectrometry. Formation of trimethylsilyl derivatives was a critical development for GC. This enabled all the major analytes to be identified and quantified in one run and the term ‘steroid profile’ for this first emerged in 1968. The use of capillary columns in place of packed columns, pioneered in the UK in th...

ea0005p247 | Steroids | BES2003

Can random urine samples substitute for 24 hour collections for steroid profiling?

Jerjes W , Taylor N

Urinary steroid profiling by capillary gas chromatography is useful for identification of disordered steroid metabolism and, when 24h collections are made, for determination of steroid production rates. We have noted a substantial clinical demand for analysis of random collections, most commonly from children with precocious puberty and a general belief that relating steroid levels to creatinine would offset the disadvantage of a short collection. Given the known circadian var...

ea0081p386 | Endocrine-Related Cancer | ECE2022

Urinary steroid metabolomics for adrenocortical cancer diagnosis. Comparison of gas chromatography mass spectrometry to liquid chromatography mass spectrometry

Taylor Angela , Bancos Irina , Gilligan Lorna , van Veen Rick , Chortis Vasileios , Shaheen Fozia , Jenkinson Carl , O'Neil Donna M , Hughes Beverly , Hawley James M , Keevil Brian , Shackelton Cedric H L , Deeks Jonathan , Sitch Alice J , Biehl Michael , Arlt Wiebke

Introduction: Gas chromatography mass spectrometry (GC-MS) is the gold standard method for urinary steroid profiling. However, GC-MS requires chemical derivatisation, long run times, is labour intensive, expensive, and unsuitable for rapid multi-sample analysis, limiting its use in routine clinical practice. GC-MS urinary steroid metabolomics, the combination of steroid profiling and machine learning (Generalized Matrix Learning Vector Quantization) was shown to have superior ...

ea0065p408 | Thyroid | SFEBES2019

Weight trajectory during treatment for hyperthyroidism

Dicasillati Gaia Alhena , Taylor Peter

Objectives: Hyperthyroidism is associated with a high basal metabolic rate and weight loss is a common symptom. However, it has been observed, that once patients are treated, they gain back the lost weight and may also put on more. Given that weight gain is a health factor, there’s interest in studying the effect that the thyroid levels have on weight gain and potential harmful health consequences.Methods: 79 patients (58 female) with hyperthyroidis...

ea0078p14 | Diabetes | BSPED2021

Level 3 Carbohydrate counting at diagnosis of Type I Diabetes Mellitus in children: How does it affect HbA1c?

Barber Wendy , Keeton Emma , Taylor Adele

Introduction: National guidance recommends Level 3 carbohydrate counting (L3CC) is delivered within 2 weeks of diagnosis of Type I Diabetes Mellitus (T1DM) (NICE, 2015). This was introduced at Derbyshire Children’s Hospital in 2017. This service evaluation aimed to assess the impact of this on patients’ blood glucose, by recording HbA1c levels at quarterly intervals over 6 months. Methods: A comparison of quarterly HbA1c in children that receiv...

ea0082we5 | Workshop E: Disorders of the gonads | SFEEU2022

A challenging case of hypogonadism

Lei Yin Win , Witczak Justyna , Taylor Peter

Gonadal dysgenesis with DAX1 duplication as the cause of XY disorder of sexual development is a rare condition. Duplication of this causes male to female sex reversal while mutation or deletion can cause adrenal hypoplasia congenita with hypogonadotropic hypogonadism. We present a case of 37-year-old lady who was referred to endocrine clinic with ongoing symptoms of fatigue. She was diagnosed with 46 XY gonadal dysgenesis when she presented with groin swelling at the ...

ea0034p373 | Steroids | SFEBES2014

Dutasteride and 5α-reductase type 1 activity: for androgens only?

West Charles , Vincent Royce , Taylor Norman

Background: Three 5α-reductase (5α-R1-3) isoenzymes are described. In humans, 5α-R2 deficiency (5α-R2D) causes pseudohermaphroditism and 5α-R3 neurological defects. The role of 5α-R1 is not clear. Urine steroid profiling (USP) by GC–MS can compare 5α-reduction activity based on excretion of 5α- and 5β-reduced metabolite ratios. Finasteride predominantly inhibits 5α-R2. USP in these patients shows concordance with 5α-R...