Searchable abstracts of presentations at key conferences in endocrinology

ea0011p832 | Thyroid | ECE2006

Insulin-like growth factor-1 counteracts 131I-induced thyroid stunning by stimulating the transcription of the sodium/iodide symporter (NIS)

Nordén M , Johanson C , Tedelind S , Larsson F , Carlsson T , Nilsson M

Thyroid stunning means reduced radioiodine uptake in thyroid tissue or tumour following a diagnostic 131I test dose. This may compromise subsequent 131I radiotherapy. Recently, we found that 131I inhibits iodide uptake in cultured thyroid cells at non-lethal absorbed doses. Here, we have investigated whether 131I irradiation affects the TSH-stimulated transcription of the sodium/iodide symporter (NIS) gene, and whether insulin-like g...

ea0041ep1128 | Thyroid cancer | ECE2016

Nuclear cysteine cathepsins in thyroid carcinomas

Al-Hashimi Alaa , Tedelind Sofia , Szumska Joanna , Dierkes N Kim , Pinzaru Alexandra , Burden Roberta , Scott Christopher , Fuhrer Dagmar , Brix Klaudia

Cysteine cathepsins are endo-lysosomal proteases that play crucial roles in thyroid physiology. However, in thyroid cancer, cathepsin B is overexpressed and secreted into the extracellular space, thus promoting migratory phenotypes of thyroid carcinoma cells through excessive extracellular matrix degradation. In addition, we have shown that N-terminally truncated forms of cathepsins B and V which lack the signal peptide and parts of the pro-peptide are localized to the nuclei ...