Endocrine Abstracts

A case of a 29-year old woman presented with a 6-year history of bone pain located in the lower spine and gradually extended to the spinal skeleton and the lower extremities, worsening by activity. The progressive symptoms and the established weakness finally led to patient’s complete disability. The investigation revealed low serum phosphorus and elevated 24 h urinary phosphate excretion, normal serum calcium and 24 h urine calcium excretion, normal to normal-high PTH an...

Aims: The Observational Study of Severe Osteoporosis (OSSO) is a 12-month, European, prospective study aiming to assess the changes in Health Related Quality of Life (HRQoL) of women with osteoporosis (OP) and an inadequate clinical response to antiresorptive (AR) medications.Methods: In Greece, 263 of 271 (97%) patients (pts) with severe OP met the inclusion criteria. The study population was assigned to1of 2 groups according to one or more of the follo...

Although bilateral inferior petrosal sinus sampling (BIPSS) is the most accurate procedure for the differential diagnosis of ACTH-dependent Cushing’s syndrome, a false-negative rate of 4–15% has been reported. An even lower sensitivity has been shown in patients with equivocal responses to CRH and/or high-dose dexamethasone suppression test (HDST). In the present study we investigated whether the administration of CRH plus desmopressin (DDAVP) during BIPPS, which is ...

Primary aldosteronism is diagnosed with increasing frequency, especially between patients with hypertension. Thus, a reliable screening test is necessary to avoid costly and demanding diagnostic procedures to this population. The aim of the present study is the evaluation of aldosterone to renine ratio (A/R) in the diagnostic algorithm of patients with hypertension with or without adrenal insidentaloma.A total of 115 subjects were studied: 13 patients wi...