Endocrine Abstracts

A 64-year-old Caucasian woman presented with hypercalcaemia in 1994 with Parathormone (PTH) of 59.9 pmol/l and corrected Calcium of 2.68 mmol/l.A parathyroid was removed and histology revealed carcinomatous change with vascular invasion suggesting probable dissemination. In November 1998 her corrected Calcium was 2.74 mmol/l with a PTH of 7.2 pmols/l but in 1999 the PTH ranged between 157 and 195 pmol/l with corrected Calcium above 2.80 mmol/l.<p cla...

Subacute thyroiditis (SAT) is a self-limited inflammatory condition of the thyroid characterised by a clinical course of hyperthyroidism, hypothyroidism, and then return to normal thyroid function. The inflammation is thought to be triggered by a viral infection and is usually treated with anti-inflammatory medications and steroids. Recurrences can uncommonly occur and could be difficult to manage. There are some promising reports of the role of Colchicine in managing recurren...

Background: Immobilisation hypercalcaemia is serious complication of prolonged immobility of any cause such as spinal cord injury, polio victims, burns victims, as well as trauma patients.Case: Eighteen-years old student was admitted to the hospital following road traffic accident. He sustained multiple fractures, skull, spine, chest and pelvis. He also sustained abdomen and pelvic haematoma. At scene of crash he had GCS 5/15, needing intubation and was ...

The Fibroblast Growth Factor 23 (FGF23) gene provides instructions for making a protein called FGF23. This protein is necessary in regulating the phosphate levels within the body. We present a case of an adult Caucasian man with persistent hypophosphatemia due to mutation in ENPP1.Case History: A 34 years old male presented with intermittent muscle pain, cramps and headaches. He also noticed episodic breathlessness and irritability. He had no hi...

Non-alcoholic steatohepatitis is part of the spectrum of non-alcoholic fatty liver disease. It is characterised by triglyceride deposition in the liver associated with a lobular hepatitis and elevated circulating aminotransferases. It is associated with insulin resistance and commonly occurs in Type 2 diabetes but is much less widely recognised in patients with Type 1 diabetes.A 29 year old Caucasian male with longstanding Type 1 diabetes presented with ...

Introduction: Pseudohyperkalaemia is one of the most common testing errors that occur in clinical practice. It’s commonly due to pre-analytical factors many of which are clinically well recognised. These include incorrect sampling, delay in sample processing and haemolysis to name a few. However non-recognition of some rarer causes like thrombocytosis often results in initial inappropriate, potentially dangerous treatment. Here we present one such case of pseudohyperkalaemia i...

Introduction: Primary hyperparathyroidism (PHPT) is a commonly encountered endocrine pathology. Asymptomatic renal stones have been reported in 7-22% of patients. NICE guideline (NG132) published in May 2019 on PHPT recommends renal US in all patients. The value of renal ultrasound for all patients with PHPT has been debated. This audit aims to compare local practice to NICE guideline (NG132) and to see if a tailored approach for renal ultrasound would be safe, practical and e...

We present a case of a 71-year-old Jamaican man who presented with a 4 weeks history of backache, lethargy, night sweats, decreased appetite, and weight loss. There was no significant medical history.Physical examination revealed tachypnoea, sinus tachycardia with evidence of short QT interval on the ECG, generalised lymphadenopathy with firm, rubbery glands up to 3×3 cm in diameter. Arterial blood gases were consistent with type 1 respiratory failu...