Endocrine Abstracts

Background: Rapid improvements in imaging have led to a 10-fold increase in the incidence of adrenal incidentalomas (AIs) over the past two decades. Delays in the diagnostic evaluation of AIs are associated with patient anxiety and significant burden on medical resources. We retrospectively audited the investigation and management of AIs at Guy’s and St Thomas’s NHS Foundation Trust (GSTT).Methods: Patients wit...

Clinical features of the primary prostate tumor remain insufficient for clinicians to accurately define patients at highest risk of developing metastases. However, the primary tumor is the source of these metastases, and thus should contain information on its metastatic potential. We hypothesized that the combination of a primary tumor’s copy number alterations (CNAs) and genome-wide transcriptome information would give us more insight in the biology of metastases-prone l...

Parathyroidectomy is the only definitive cure for primary hyperparathyroidism (PHPT). The standard for pre-operative localisation of parathyroid pathology at our institution is both a (99m)Tc-sestamibi SPECT/CT (sestamibi) and neck ultrasound scan (USS). The aim of this audit was to assess the accuracy of this standard pre-operative imaging.Methods: Retrospective data was gathered from all parathyroidectomies performed at St Thomas’ Hospital between...

Hypoglycaemia is often referred to Endocrinology for investigation and management. Occasionally, these referrals are in the context of malignancy and we seek to exclude ectopic insulin secretion, as well as other causes. This case highlights a less recognised cause for hypoglycaemia in haematological malignancy. The patient, a 78 year-old man with advanced Mantle Cell Lymphoma presented with hypoglycaemia and was admitted under Haematology, who had been treating with chemother...

Over the past decade, annual spending on pharmaceutical development to treat many endocrinological systems has increased exponentially. At the same time, in spite of these huge sums invested, the average number of drugs being approved for human use has decreased to one in ten. Currently, preclinical studies to test the safety and efficiency of new drugs, use laboratory animals and traditional 2D cell culture models. Neither of these methods are completely accurate reflections ...

Over the past decade, annual spending on pharmaceutical development to treat many endocrinological systems has increased exponentially. At the same time, in spite of these huge sums invested, the average number of drugs being approved for human use has decreased to one in ten. Currently, preclinical studies to test the safety and efficiency of new drugs, use laboratory animals and traditional 2D cell culture models. Neither of these methods are completely accurate reflections ...

The mature 37 amino acid peptide amylin is derived from the IAPP (islet amyloid polypeptide) gene and is produced in pancreatic beta-cells and – in much lower amounts – in other tissues, like the stomach, spinal ganglia and in the brain. Amylin is characterized by an interesting dichotomy because amylin has to propensity to aggregate into fibrils in some species, but on the other hand also to the physiological control of metabolism (probably in all species). These di...

Thyroid hormone plays a critical role in the production and maintenance of myelin, the lipid-rich sheath that surrounds the outer surface of axons. Myelin is made from processes that extend from oligodendrocytes (OL), a glia cell that comprises about 20% of the cells in the adult central nervous system (CNS). Mature, myelinating OL are produced from a differentiation pathway that begins with neural stem cells and involves the differentiation of oligodendrocyte progenitor cells...

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